Entity Details

Primary name PLS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15162
EntryNamePLS1_HUMAN
FullNamePhospholipid scramblase 1
TaxID9606
Evidenceevidence at protein level
Length318
SequenceStatuscomplete
DateCreated2001-06-20
DateModified2021-06-02

Ontological Relatives

GenesPLSCR1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001618 virus receptor activity
GO:0003677 DNA binding
GO:0004518 nuclease activity
GO:0005154 epidermal growth factor receptor binding
GO:0005509 calcium ion binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006659 phosphatidylserine biosynthetic process
GO:0006915 apoptotic process
GO:0006953 acute-phase response
GO:0008270 zinc ion binding
GO:0010288 response to lead ion
GO:0010628 positive regulation of gene expression
GO:0016020 membrane
GO:0017121 plasma membrane phospholipid scrambling
GO:0017124 SH3 domain binding
GO:0017128 phospholipid scramblase activity
GO:0019899 enzyme binding
GO:0030168 platelet activation
GO:0032791 lead ion binding
GO:0033003 regulation of mast cell activation
GO:0035456 response to interferon-beta
GO:0042609 CD4 receptor binding
GO:0045071 negative regulation of viral genome replication
GO:0045089 positive regulation of innate immune response
GO:0045121 membrane raft
GO:0045340 mercury ion binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048471 perinuclear region of cytoplasm
GO:0050765 negative regulation of phagocytosis
GO:0051607 defense response to virus
GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070782 phosphatidylserine exposure on apoptotic cell surface
GO:1905820 positive regulation of chromosome separation
GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR005552 ScramblaseFamilyFamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PLS1_HUMANHXA1_MOUSEIntAct23088713 details