Entity Details

Primary name TIF1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15164
EntryNameTIF1A_HUMAN
FullNameTranscription intermediary factor 1-alpha
TaxID9606
Evidenceevidence at protein level
Length1050
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesTRIM24

GO terms

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GOName
GO:0000791 euchromatin
GO:0002039 p53 binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0004672 protein kinase activity
GO:0005102 signaling receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005726 perichromatin fibrils
GO:0005829 cytosol
GO:0006366 transcription by RNA polymerase II
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0016567 protein ubiquitination
GO:0016922 nuclear receptor binding
GO:0030163 protein catabolic process
GO:0031647 regulation of protein stability
GO:0034056 estrogen response element binding
GO:0042981 regulation of apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
GO:0055074 calcium ion homeostasis
GO:0061630 ubiquitin protein ligase activity
GO:0070562 regulation of vitamin D receptor signaling pathway
GO:0070577 lysine-acetylated histone binding
GO:0071391 cellular response to estrogen stimulus
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000315 B-box-type zinc fingerDomainDomain
IPR001487 BromodomainDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR003649 B-box, C-terminalDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR018359 Bromodomain, conserved siteSiteConserved site
IPR019786 Zinc finger, PHD-type, conserved siteSiteConserved site
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR036427 Bromodomain-like superfamilyFamilyHomologous superfamily

Diseases

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Interactions

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