Entity Details

Primary name AXIN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15169
EntryNameAXIN1_HUMAN
FullNameAxin-1
TaxID9606
Evidenceevidence at protein level
Length862
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesAXIN1

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0007275 multicellular organism development
GO:0008013 beta-catenin binding
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0016055 Wnt signaling pathway
GO:0016328 lateral plasma membrane
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030111 regulation of Wnt signaling pathway
GO:0030159 signaling receptor complex adaptor activity
GO:0030877 beta-catenin destruction complex
GO:0031398 positive regulation of protein ubiquitination
GO:0031410 cytoplasmic vesicle
GO:0031625 ubiquitin protein ligase binding
GO:0032147 activation of protein kinase activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0034622 cellular protein-containing complex assembly
GO:0035591 signaling adaptor activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0045732 positive regulation of protein catabolic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046330 positive regulation of JNK cascade
GO:0046332 SMAD binding
GO:0048471 perinuclear region of cytoplasm
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0060090 molecular adaptor activity
GO:0070016 armadillo repeat domain binding
GO:0070411 I-SMAD binding
GO:0071944 cell periphery
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1904885 beta-catenin destruction complex assembly
GO:1904886 beta-catenin destruction complex disassembly
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001158 DIX domainDomainDomain
IPR014936 Axin beta-catenin bindingDomainDomain
IPR016137 RGS domainDomainDomain
IPR024066 RGS, subdomain 1/3FamilyHomologous superfamily
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR029797 Axin-1FamilyFamily
IPR032101 Axin-1/2, tankyrase-binding domainDomainDomain
IPR036305 RGS domain superfamilyFamilyHomologous superfamily
IPR038207 DIX domain superfamilyFamilyHomologous superfamily
IPR043581 Axin-likeFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB04447 1,4-DithiothreitolDrugbanksmall molecule

Interactions

4 interactions