Entity Details

Primary name TRI18_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15344
EntryNameTRI18_HUMAN
FullNameE3 ubiquitin-protein ligase Midline-1
TaxID9606
Evidenceevidence at protein level
Length667
SequenceStatuscomplete
DateCreated2002-08-30
DateModified2021-06-02

Ontological Relatives

GenesMID1

GO terms

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GOName
GO:0000226 microtubule cytoskeleton organization
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0007389 pattern specification process
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0019899 enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0035372 protein localization to microtubule
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0051219 phosphoprotein binding
GO:0060333 interferon-gamma-mediated signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000315 B-box-type zinc fingerDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR001870 B30.2/SPRY domainDomainDomain
IPR003649 B-box, C-terminalDomainDomain
IPR003877 SPRY domainDomainDomain
IPR003879 Butyrophylin-like, SPRY domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR006574 SPRY-associatedDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017903 COS domainDomainDomain
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR027370 RING-type zinc-finger, LisH dimerisation motifDomainDomain
IPR027727 Midline-1FamilyFamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR040859 Midline-1, COS domainDomainDomain
IPR043136 B30.2/SPRY domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
TRI18_HUMANIGBP1_MOUSEBioGRID11806752 details
TRI18_HUMANHM20B_MOUSEBioGRID28760657 details