Entity Details

Primary name P73_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15350
EntryNameP73_HUMAN
FullNameTumor protein p73
TaxID9606
Evidenceevidence at protein level
Length636
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesTP73

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001822 kidney development
GO:0002039 p53 binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006298 mismatch repair
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006974 cellular response to DNA damage stimulus
GO:0007346 regulation of mitotic cell cycle
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010243 response to organonitrogen compound
GO:0010468 regulation of gene expression
GO:0016032 viral process
GO:0019901 protein kinase binding
GO:0030054 cell junction
GO:0042493 response to drug
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0045665 negative regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0051262 protein tetramerization
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0097371 MDM2/MDM4 family protein binding
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902036 regulation of hematopoietic stem cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001660 Sterile alpha motif domainDomainDomain
IPR002117 p53 tumour suppressor familyFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR010991 p53, tetramerisation domainDomainDomain
IPR011615 p53, DNA-binding domainDomainDomain
IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR032646 Tumour protein p73FamilyFamily
IPR036674 p53-like tetramerisation domain superfamilyFamilyHomologous superfamily
IPR037612 Tumour protein p73, SAM domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

3 interactions