Entity Details

Primary name SHIP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15357
EntryNameSHIP2_HUMAN
FullNamePhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
TaxID9606
Evidenceevidence at protein level
Length1258
SequenceStatuscomplete
DateCreated2007-09-11
DateModified2021-06-02

Ontological Relatives

GenesINPPL1

GO terms

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GOName
GO:0001958 endochondral ossification
GO:0002376 immune system process
GO:0003779 actin binding
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006006 glucose metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006897 endocytosis
GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0008285 negative regulation of cell population proliferation
GO:0009791 post-embryonic development
GO:0010629 negative regulation of gene expression
GO:0016607 nuclear speck
GO:0017124 SH3 domain binding
GO:0019221 cytokine-mediated signaling pathway
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0032868 response to insulin
GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0042169 SH2 domain binding
GO:0043647 inositol phosphate metabolic process
GO:0046856 phosphatidylinositol dephosphorylation
GO:0097178 ruffle assembly

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Membrane
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR000300 Inositol polyphosphate-related phosphataseDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001660 Sterile alpha motif domainDomainDomain
IPR005135 Endonuclease/exonuclease/phosphataseDomainDomain
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR036691 Endonuclease/exonuclease/phosphatase superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
SHIP2_HUMANGAB1_MOUSEMINT10871282 details