Entity Details

Primary name HDAC3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15379
EntryNameHDAC3_HUMAN
FullNameHistone deacetylase 3
TaxID9606
Evidenceevidence at protein level
Length428
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesHDAC3

GO terms

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GOName
GO:0000118 histone deacetylase complex
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001934 positive regulation of protein phosphorylation
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006325 chromatin organization
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006476 protein deacetylation
GO:0007623 circadian rhythm
GO:0008134 transcription factor binding
GO:0017053 transcription repressor complex
GO:0019216 regulation of lipid metabolic process
GO:0019899 enzyme binding
GO:0030332 cyclin binding
GO:0030522 intracellular receptor signaling pathway
GO:0031398 positive regulation of protein ubiquitination
GO:0031647 regulation of protein stability
GO:0032008 positive regulation of TOR signaling
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032922 circadian regulation of gene expression
GO:0033558 protein deacetylase activity
GO:0042307 positive regulation of protein import into nucleus
GO:0042752 regulation of circadian rhythm
GO:0042826 histone deacetylase binding
GO:0043066 negative regulation of apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046329 negative regulation of JNK cascade
GO:0051059 NF-kappaB binding
GO:0051225 spindle assembly
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0071498 cellular response to fluid shear stress
GO:0072686 mitotic spindle
GO:0120162 positive regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000286 Histone deacetylase familyFamilyFamily
IPR003084 Histone deacetylaseFamilyFamily
IPR023696 Ureohydrolase domain superfamilyFamilyHomologous superfamily
IPR023801 Histone deacetylase domainDomainDomain
IPR037138 Histone deacetylase domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02546 VorinostatDrugbanksmall molecule
DB05015 BelinostatDrugbanksmall molecule
DB05223 PracinostatDrugbanksmall molecule
DB06603 PanobinostatDrugbanksmall molecule
DB11830 MocetinostatDrugbanksmall molecule