Entity Details

Primary name CFLAR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15519
EntryNameCFLAR_HUMAN
FullNameCASP8 and FADD-like apoptosis regulator
TaxID9606
Evidenceevidence at protein level
Length480
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesCFLAR

GO terms

Show/Hide Table
GOName
GO:0002020 protease binding
GO:0005123 death receptor binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007519 skeletal muscle tissue development
GO:0008047 enzyme activator activity
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0010976 positive regulation of neuron projection development
GO:0014732 skeletal muscle atrophy
GO:0014842 regulation of skeletal muscle satellite cell proliferation
GO:0014866 skeletal myofibril assembly
GO:0016032 viral process
GO:0031264 death-inducing signaling complex
GO:0031265 CD95 death-inducing signaling complex
GO:0032869 cellular response to insulin stimulus
GO:0033574 response to testosterone
GO:0042060 wound healing
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043403 skeletal muscle tissue regeneration
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060544 regulation of necroptotic process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071456 cellular response to hypoxia
GO:0071549 cellular response to dexamethasone stimulus
GO:0071732 cellular response to nitric oxide
GO:0072126 positive regulation of glomerular mesangial cell proliferation
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0097342 ripoptosome
GO:1901740 negative regulation of myoblast fusion
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903055 positive regulation of extracellular matrix organization
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus
GO:1903944 negative regulation of hepatocyte apoptotic process
GO:2000347 positive regulation of hepatocyte proliferation
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

Show/Hide Table

Domains

Show/Hide Table
DomainNameCategoryType
IPR001309 Peptidase C14, p20 domainDomainDomain
IPR001875 Death effector domainDomainDomain
IPR002398 Peptidase C14 familyFamilyFamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR015917 Peptidase C14A, caspase catalytic domainDomainDomain
IPR029030 Caspase-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
CFLAR_HUMANMIB1_MOUSEBioGRID19710364 details