Entity Details

Primary name SOCS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15524
EntryNameSOCS1_HUMAN
FullNameSuppressor of cytokine signaling 1
TaxID9606
Evidenceevidence at protein level
Length211
SequenceStatuscomplete
DateCreated2002-04-16
DateModified2021-06-02

Ontological Relatives

GenesSOCS1

GO terms

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GOName
GO:0001817 regulation of cytokine production
GO:0001932 regulation of protein phosphorylation
GO:0004860 protein kinase inhibitor activity
GO:0005159 insulin-like growth factor receptor binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0010533 regulation of activation of Janus kinase activity
GO:0016567 protein ubiquitination
GO:0019210 kinase inhibitor activity
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0031410 cytoplasmic vesicle
GO:0035556 intracellular signal transduction
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0038111 interleukin-7-mediated signaling pathway
GO:0040008 regulation of growth
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043377 negative regulation of CD8-positive, alpha-beta T cell differentiation
GO:0045444 fat cell differentiation
GO:0045591 positive regulation of regulatory T cell differentiation
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0071230 cellular response to amino acid stimulus

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Nucleus

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001496 SOCS box domainDomainDomain
IPR028411 Suppressor of cytokine signalling 1FamilyFamily
IPR035861 SOCS1, SH2 domainDomainDomain
IPR036036 SOCS box-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
SOCS1_HUMANNECT4_MOUSEBioGRID28258213 details
SOCS1_HUMANNECT3_MOUSEBioGRID28258213 details