Entity Details

Primary name PDPK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15530
EntryNamePDPK1_HUMAN
FullName3-phosphoinositide-dependent protein kinase 1
TaxID9606
Evidenceevidence at protein level
Length556
SequenceStatuscomplete
DateCreated2001-10-18
DateModified2021-06-02

Ontological Relatives

GenesPDPK1

GO terms

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GOName
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0003323 type B pancreatic cell development
GO:0004674 protein serine/threonine kinase activity
GO:0004676 3-phosphoinositide-dependent protein kinase activity
GO:0005158 insulin receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006972 hyperosmotic response
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0010518 positive regulation of phospholipase activity
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0014069 postsynaptic density
GO:0016004 phospholipase activator activity
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019722 calcium-mediated signaling
GO:0019901 protein kinase binding
GO:0030036 actin cytoskeleton organization
GO:0030168 platelet activation
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031295 T cell costimulation
GO:0031410 cytoplasmic vesicle
GO:0032148 activation of protein kinase B activity
GO:0032869 cellular response to insulin stimulus
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042995 cell projection
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043204 perikaryon
GO:0043274 phospholipase binding
GO:0043304 regulation of mast cell degranulation
GO:0043524 negative regulation of neuron apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0046777 protein autophosphorylation
GO:0048041 focal adhesion assembly
GO:0050852 T cell receptor signaling pathway
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051897 positive regulation of protein kinase B signaling
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0097191 extrinsic apoptotic signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903672 positive regulation of sprouting angiogenesis
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:1990416 cellular response to brain-derived neurotrophic factor stimulus
GO:2000352 negative regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR033931 PDK1-type, PH domainDomainDomain
IPR039046 PDPK1 familyFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00482 CelecoxibDrugbanksmall molecule
DB01863 Inositol 1,3,4,5-TetrakisphosphateDrugbanksmall molecule
DB01933 7-HydroxystaurosporineDrugbanksmall molecule
DB01946 Bisindolylmaleimide VIIIDrugbanksmall molecule
DB02010 StaurosporineDrugbanksmall molecule
DB03777 Bisindolylmaleimide IDrugbanksmall molecule
DB04522 DexfosfoserineDrugbanksmall molecule
DB06932 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamineDrugbanksmall molecule
DB07033 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONEDrugbanksmall molecule
DB07132 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREADrugbanksmall molecule
DB07300 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amineDrugbanksmall molecule
DB07456 3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dioneDrugbanksmall molecule
DB07457 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONEDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PDPK1_HUMANAKT1_MOUSEBioGRID19662498 details