Entity Details

Primary name SIAH2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43255
EntryNameSIAH2_HUMAN
FullNameE3 ubiquitin-protein ligase SIAH2
TaxID9606
Evidenceevidence at protein level
Length324
SequenceStatuscomplete
DateCreated2004-04-26
DateModified2021-06-02

Ontological Relatives

GenesSIAH2

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0003714 transcription corepressor activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0007264 small GTPase mediated signal transduction
GO:0007275 multicellular organism development
GO:0008270 zinc ion binding
GO:0016579 protein deubiquitination
GO:0031396 regulation of protein ubiquitination
GO:0031624 ubiquitin conjugating enzyme binding
GO:0042752 regulation of circadian rhythm
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043231 intracellular membrane-bounded organelle
GO:0044257 cellular protein catabolic process
GO:0048511 rhythmic process
GO:0061630 ubiquitin protein ligase activity
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1902842 negative regulation of netrin-activated signaling pathway
GO:1990000 amyloid fibril formation
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR004162 E3 ubiquitin-protein ligase SINA-like, animalFamilyFamily
IPR008974 TRAF-likeFamilyHomologous superfamily
IPR013010 Zinc finger, SIAH-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR018121 Seven-in-absentia protein, TRAF-like domainDomainDomain

Diseases

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Interactions

3 interactions