Entity Details

Primary name FOXO3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43524
EntryNameFOXO3_HUMAN
FullNameForkhead box protein O3
TaxID9606
Evidenceevidence at protein level
Length673
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesFOXO3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006390 mitochondrial transcription
GO:0006417 regulation of translation
GO:0006915 apoptotic process
GO:0008013 beta-catenin binding
GO:0010508 positive regulation of autophagy
GO:0014737 positive regulation of muscle atrophy
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0030336 negative regulation of cell migration
GO:0031490 chromatin DNA binding
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034246 mitochondrial transcription factor activity
GO:0034599 cellular response to oxidative stress
GO:0042149 cellular response to glucose starvation
GO:0042594 response to starvation
GO:0043065 positive regulation of apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0070542 response to fatty acid
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion matrix
Mitochondrion outer membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001766 Fork head domainDomainDomain
IPR030456 Fork head domain conserved site 2SiteConserved site
IPR032067 FOXO protein, transactivation domainDomainDomain
IPR032068 FOXO protein, KIX-binding domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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