Entity Details

Primary name SPY1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43609
EntryNameSPY1_HUMAN
FullNameProtein sprouty homolog 1
TaxID9606
Evidenceevidence at protein level
Length319
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesSPRY1

GO terms

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GOName
GO:0000132 establishment of mitotic spindle orientation
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001759 organ induction
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008285 negative regulation of cell population proliferation
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0034260 negative regulation of GTPase activity
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0043407 negative regulation of MAP kinase activity
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048513 animal organ development
GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway
GO:0060449 bud elongation involved in lung branching
GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:1902747 negative regulation of lens fiber cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR007875 SproutyFamilyFamily
IPR030783 Protein sprouty homologue 1FamilyFamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
SPY1_HUMANHXA1_MOUSEIntAct23088713 details