Entity Details

Primary name NCK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43639
EntryNameNCK2_HUMAN
FullNameCytoplasmic protein NCK2
TaxID9606
Evidenceevidence at protein level
Length380
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesNCK2

GO terms

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GOName
GO:0001771 immunological synapse formation
GO:0001784 phosphotyrosine residue binding
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0007015 actin filament organization
GO:0007165 signal transduction
GO:0007172 signal complex assembly
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007176 regulation of epidermal growth factor-activated receptor activity
GO:0008093 cytoskeletal anchor activity
GO:0008285 negative regulation of cell population proliferation
GO:0012506 vesicle membrane
GO:0014069 postsynaptic density
GO:0016477 cell migration
GO:0030032 lamellipodium assembly
GO:0030159 signaling receptor complex adaptor activity
GO:0030838 positive regulation of actin filament polymerization
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035591 signaling adaptor activity
GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0044877 protein-containing complex binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0060996 dendritic spine development
GO:0097110 scaffold protein binding
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903898 negative regulation of PERK-mediated unfolded protein response
GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR017304 Cytoplasmic protein NCKFamilyFamily
IPR028524 Cytoplasmic protein NCK2FamilyFamily
IPR035559 Nck2, SH3 domain 1DomainDomain
IPR035560 Nck2, SH3 domain 2DomainDomain
IPR035561 Nck2, SH3 domain 3DomainDomain
IPR035883 Nck2, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
NCK2_HUMANPGFRB_MOUSEBioGRID9843575 details