Entity Details

Primary name ACTN4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43707
EntryNameACTN4_HUMAN
FullNameAlpha-actinin-4
TaxID9606
Evidenceevidence at protein level
Length911
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesACTN4

GO terms

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GOName
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001666 response to hypoxia
GO:0001725 stress fiber
GO:0001882 nucleoside binding
GO:0002576 platelet degranulation
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0015031 protein transport
GO:0016604 nuclear body
GO:0030050 vesicle transport along actin filament
GO:0030335 positive regulation of cell migration
GO:0030374 nuclear receptor coactivator activity
GO:0031093 platelet alpha granule lumen
GO:0031143 pseudopodium
GO:0031490 chromatin DNA binding
GO:0032417 positive regulation of sodium:proton antiporter activity
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0042803 protein homodimerization activity
GO:0042974 retinoic acid receptor binding
GO:0042981 regulation of apoptotic process
GO:0043005 neuron projection
GO:0044325 transmembrane transporter binding
GO:0047485 protein N-terminus binding
GO:0048384 retinoic acid receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0051015 actin filament binding
GO:0051272 positive regulation of cellular component movement
GO:0070062 extracellular exosome
GO:1900025 negative regulation of substrate adhesion-dependent cell spreading
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1903506 regulation of nucleic acid-templated transcription
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001589 Actinin-type actin-binding domain, conserved siteSiteConserved site
IPR001715 Calponin homology domainDomainDomain
IPR002017 Spectrin repeatRepeatRepeat
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR014837 EF-hand, Ca insensitiveDomainDomain
IPR018159 Spectrin/alpha-actininRepeatRepeat
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR036872 CH domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

0 interactions

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