Entity Details

Primary name AIRE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43918
EntryNameAIRE_HUMAN
FullNameAutoimmune regulator
TaxID9606
Evidenceevidence at protein level
Length545
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesAIRE

GO terms

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GOName
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0002458 peripheral T cell tolerance induction
GO:0002509 central tolerance induction to self antigen
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006955 immune response
GO:0006959 humoral immune response
GO:0008270 zinc ion binding
GO:0016604 nuclear body
GO:0032722 positive regulation of chemokine production
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0045060 negative thymic T cell selection
GO:0045182 translation regulator activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0097536 thymus epithelium morphogenesis
GO:2000410 regulation of thymocyte migration

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000770 SAND domainDomainDomain
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR004865 HSR domainDomainDomain
IPR008087 Autoimmune regulator, AIREFamilyFamily
IPR010919 SAND-like domain superfamilyFamilyHomologous superfamily
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR019786 Zinc finger, PHD-type, conserved siteSiteConserved site
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR042580 AIRE, PHD finger 2DomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
AIRE_HUMANNASP_MOUSEIntAct20085707 details
AIRE_HUMANMBB1A_MOUSEIntAct20085707 details