Entity Details

Primary name PRKN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60260
EntryNamePRKN_HUMAN
FullNameE3 ubiquitin-protein ligase parkin
TaxID9606
Evidenceevidence at protein level
Length465
SequenceStatuscomplete
DateCreated2004-10-11
DateModified2021-06-02

Ontological Relatives

GenesPRKN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000151 ubiquitin ligase complex
GO:0000209 protein polyubiquitination
GO:0000266 mitochondrial fission
GO:0000422 autophagy of mitochondrion
GO:0000423 mitophagy
GO:0001664 G protein-coupled receptor binding
GO:0001933 negative regulation of protein phosphorylation
GO:0001964 startle response
GO:0003714 transcription corepressor activity
GO:0003779 actin binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0006979 response to oxidative stress
GO:0007005 mitochondrion organization
GO:0007417 central nervous system development
GO:0007612 learning
GO:0008013 beta-catenin binding
GO:0008270 zinc ion binding
GO:0008344 adult locomotory behavior
GO:0010498 proteasomal protein catabolic process
GO:0010506 regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010636 positive regulation of mitochondrial fusion
GO:0010637 negative regulation of mitochondrial fusion
GO:0010821 regulation of mitochondrion organization
GO:0010906 regulation of glucose metabolic process
GO:0010994 free ubiquitin chain polymerization
GO:0014059 regulation of dopamine secretion
GO:0014069 postsynaptic density
GO:0015631 tubulin binding
GO:0016235 aggresome
GO:0016236 macroautophagy
GO:0016567 protein ubiquitination
GO:0016579 protein deubiquitination
GO:0016607 nuclear speck
GO:0017124 SH3 domain binding
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0030165 PDZ domain binding
GO:0030544 Hsp70 protein binding
GO:0031072 heat shock protein binding
GO:0031396 regulation of protein ubiquitination
GO:0031624 ubiquitin conjugating enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0031647 regulation of protein stability
GO:0031648 protein destabilization
GO:0032092 positive regulation of protein binding
GO:0032232 negative regulation of actin filament bundle assembly
GO:0032368 regulation of lipid transport
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033132 negative regulation of glucokinase activity
GO:0034620 cellular response to unfolded protein
GO:0034976 response to endoplasmic reticulum stress
GO:0035249 synaptic transmission, glutamatergic
GO:0035519 protein K29-linked ubiquitination
GO:0035973 aggrephagy
GO:0036503 ERAD pathway
GO:0042053 regulation of dopamine metabolic process
GO:0042415 norepinephrine metabolic process
GO:0042417 dopamine metabolic process
GO:0042802 identical protein binding
GO:0042826 histone deacetylase binding
GO:0042981 regulation of apoptotic process
GO:0043005 neuron projection
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043130 ubiquitin binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043274 phospholipase binding
GO:0043388 positive regulation of DNA binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0044257 cellular protein catabolic process
GO:0044314 protein K27-linked ubiquitination
GO:0044828 negative regulation by host of viral genome replication
GO:0044877 protein-containing complex binding
GO:0045732 positive regulation of protein catabolic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046329 negative regulation of JNK cascade
GO:0046676 negative regulation of insulin secretion
GO:0048471 perinuclear region of cytoplasm
GO:0050821 protein stabilization
GO:0051087 chaperone binding
GO:0051582 positive regulation of neurotransmitter uptake
GO:0051583 dopamine uptake involved in synaptic transmission
GO:0051865 protein autoubiquitination
GO:0051881 regulation of mitochondrial membrane potential
GO:0055069 zinc ion homeostasis
GO:0060548 negative regulation of cell death
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0061630 ubiquitin protein ligase activity
GO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:0070050 neuron cellular homeostasis
GO:0070534 protein K63-linked ubiquitination
GO:0070585 protein localization to mitochondrion
GO:0070842 aggresome assembly
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
GO:0071287 cellular response to manganese ion
GO:0085020 protein K6-linked ubiquitination
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090141 positive regulation of mitochondrial fission
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0097237 cellular response to toxic substance
GO:0097413 Lewy body
GO:0097602 cullin family protein binding
GO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization
GO:0098793 presynapse
GO:0099074 mitochondrion to lysosome transport
GO:1900407 regulation of cellular response to oxidative stress
GO:1901215 negative regulation of neuron death
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1902283 negative regulation of primary amine oxidase activity
GO:1902530 positive regulation of protein linear polyubiquitination
GO:1902803 regulation of synaptic vesicle transport
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:1903214 regulation of protein targeting to mitochondrion
GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway
GO:1903351 cellular response to dopamine
GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903382 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903542 negative regulation of exosomal secretion
GO:1903599 positive regulation of autophagy of mitochondrion
GO:1903861 positive regulation of dendrite extension
GO:1904049 negative regulation of spontaneous neurotransmitter secretion
GO:1905281 positive regulation of retrograde transport, endosome to Golgi
GO:1905366 negative regulation of intralumenal vesicle formation
GO:1905477 positive regulation of protein localization to membrane
GO:1990000 amyloid fibril formation
GO:1990381 ubiquitin-specific protease binding
GO:1990444 F-box domain binding
GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000378 negative regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cell junction
Cell projection
Cytoplasm
Endoplasmic reticulum
Mitochondrion
Mitochondrion outer membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000626 Ubiquitin-like domainDomainDomain
IPR002867 IBR domainDomainDomain
IPR003977 E3 ubiquitin-protein ligase parkinFamilyFamily
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR041170 RING/Ubox-like zinc-binding domainDomainDomain
IPR041565 Parkin, RING/Ubox like zinc-binding domainDomainDomain
IPR044066 TRIAD supradomainDomainDomain

Diseases

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