Entity Details

Primary name KDM1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60341
EntryNameKDM1A_HUMAN
FullNameLysine-specific histone demethylase 1A
TaxID9606
Evidenceevidence at protein level
Length852
SequenceStatuscomplete
DateCreated2004-08-16
DateModified2021-06-02

Ontological Relatives

GenesKDM1A

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000380 alternative mRNA splicing, via spliceosome
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0002039 p53 binding
GO:0002052 positive regulation of neuroblast proliferation
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006482 protein demethylation
GO:0007596 blood coagulation
GO:0008134 transcription factor binding
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0010976 positive regulation of neuron projection development
GO:0016491 oxidoreductase activity
GO:0019899 enzyme binding
GO:0021987 cerebral cortex development
GO:0030374 nuclear receptor coactivator activity
GO:0030522 intracellular receptor signaling pathway
GO:0032091 negative regulation of protein binding
GO:0032451 demethylase activity
GO:0032452 histone demethylase activity
GO:0032453 histone demethylase activity (H3-K4 specific)
GO:0032454 histone demethylase activity (H3-K9 specific)
GO:0032991 protein-containing complex
GO:0033169 histone H3-K9 demethylation
GO:0033184 positive regulation of histone ubiquitination
GO:0034644 cellular response to UV
GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)
GO:0034720 histone H3-K4 demethylation
GO:0035563 positive regulation of chromatin binding
GO:0042551 neuron maturation
GO:0043392 negative regulation of DNA binding
GO:0043426 MRF binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045793 positive regulation of cell size
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046098 guanine metabolic process
GO:0050660 flavin adenine dinucleotide binding
GO:0050681 androgen receptor binding
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051572 negative regulation of histone H3-K4 methylation
GO:0051573 negative regulation of histone H3-K9 methylation
GO:0055001 muscle cell development
GO:0060765 regulation of androgen receptor signaling pathway
GO:0060992 response to fungicide
GO:0061752 telomeric repeat-containing RNA binding
GO:0071320 cellular response to cAMP
GO:0071480 cellular response to gamma radiation
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1903827 regulation of cellular protein localization
GO:1990391 DNA repair complex
GO:1990841 promoter-specific chromatin binding
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2000648 positive regulation of stem cell proliferation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR002937 Amine oxidaseDomainDomain
IPR007526 SWIRM domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017366 Histone lysine-specific demethylaseFamilyFamily
IPR036188 FAD/NAD(P)-binding domain superfamilyFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

4 interactions