Entity Details

Primary name PHLP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60346
EntryNamePHLP1_HUMAN
FullNamePH domain leucine-rich repeat-containing protein phosphatase 1
TaxID9606
Evidenceevidence at protein level
Length1717
SequenceStatuscomplete
DateCreated2005-06-07
DateModified2021-06-02

Ontological Relatives

GenesPHLPP1

GO terms

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GOName
GO:0002667 regulation of T cell anergy
GO:0004722 protein serine/threonine phosphatase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0009649 entrainment of circadian clock
GO:0042981 regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043408 regulation of MAPK cascade
GO:0046328 regulation of JNK cascade
GO:0046872 metal ion binding
GO:0051898 negative regulation of protein kinase B signaling
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:1900744 regulation of p38MAPK cascade

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001611 Leucine-rich repeatRepeatRepeat
IPR001849 Pleckstrin homology domainDomainDomain
IPR001932 PPM-type phosphatase domainDomainDomain
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR036457 PPM-type phosphatase domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PHLP1_HUMANSCRIB_MOUSEMINT21701506 details