Entity Details

Primary name JAK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60674
EntryNameJAK2_HUMAN
FullNameTyrosine-protein kinase JAK2
TaxID9606
Evidenceevidence at protein level
Length1132
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesJAK2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0000791 euchromatin
GO:0001774 microglial cell activation
GO:0002250 adaptive immune response
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005131 growth hormone receptor binding
GO:0005143 interleukin-12 receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0007498 mesoderm development
GO:0007596 blood coagulation
GO:0008022 protein C-terminus binding
GO:0008285 negative regulation of cell population proliferation
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010811 positive regulation of cell-substrate adhesion
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0020037 heme binding
GO:0022408 negative regulation of cell-cell adhesion
GO:0030041 actin filament polymerization
GO:0030154 cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030335 positive regulation of cell migration
GO:0031103 axon regeneration
GO:0031702 type 1 angiotensin receptor binding
GO:0031904 endosome lumen
GO:0031959 mineralocorticoid receptor signaling pathway
GO:0032024 positive regulation of insulin secretion
GO:0032496 response to lipopolysaccharide
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033130 acetylcholine receptor binding
GO:0033194 response to hydroperoxide
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034612 response to tumor necrosis factor
GO:0035401 histone kinase activity (H3-Y41 specific)
GO:0035409 histone H3-Y41 phosphorylation
GO:0035556 intracellular signal transduction
GO:0035722 interleukin-12-mediated signaling pathway
GO:0038155 interleukin-23-mediated signaling pathway
GO:0042169 SH2 domain binding
GO:0042307 positive regulation of protein import into nucleus
GO:0042393 histone binding
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802 identical protein binding
GO:0042976 activation of Janus kinase activity
GO:0042981 regulation of apoptotic process
GO:0043388 positive regulation of DNA binding
GO:0043392 negative regulation of DNA binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
GO:0045121 membrane raft
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045428 regulation of nitric oxide biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045597 positive regulation of cell differentiation
GO:0045822 negative regulation of heart contraction
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046677 response to antibiotic
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050804 modulation of chemical synaptic transmission
GO:0050867 positive regulation of cell activation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051428 peptide hormone receptor binding
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060396 growth hormone receptor signaling pathway
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0060399 positive regulation of growth hormone receptor signaling pathway
GO:0061180 mammary gland epithelium development
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070106 interleukin-27-mediated signaling pathway
GO:0070671 response to interleukin-12
GO:0070757 interleukin-35-mediated signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0099527 postsynapse to nucleus signaling pathway
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
GO:1904037 positive regulation of epithelial cell apoptotic process
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:2000273 positive regulation of signaling receptor activity

Subcellular Location

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Subcellular Location
Cytoplasm
Endomembrane system
Nucleus

Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR019749 Band 4.1 domainDomainDomain
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR020693 Tyrosine-protein kinase, non-receptor Jak2FamilyFamily
IPR035588 Janus kinase 2, pseudokinase domainDomainDomain
IPR035589 Janus kinase 2, catalytic domainDomainDomain
IPR035860 Tyrosine-protein kinase JAK2, SH2 domainDomainDomain
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR037838 JAK2, FERM domain C-lobeDomainDomain
IPR041046 JAK, FERM F2 lobe domainDomainDomain
IPR041155 FERM F1 lobe ubiquitin-like domainDomainDomain
IPR041381 Jak1, pleckstrin homology-like domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB04716 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-oneDrugbanksmall molecule
DB05243 XL019Drugbanksmall molecule
DB07161 5-phenyl-1H-indazol-3-amineDrugbanksmall molecule
DB07162 4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamideDrugbanksmall molecule
DB08067 4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUMDrugbanksmall molecule
DB08877 RuxolitinibDrugbanksmall molecule
DB08895 TofacitinibDrugbanksmall molecule
DB11817 BaricitinibDrugbanksmall molecule
DB11986 EntrectinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12500 FedratinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule