Entity Details

Primary name NBN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60934
EntryNameNBN_HUMAN
FullNameNibrin
TaxID9606
Evidenceevidence at protein level
Length754
SequenceStatuscomplete
DateCreated2006-04-04
DateModified2021-06-02

Ontological Relatives

GenesNBN

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000729 DNA double-strand break processing
GO:0000781 chromosome, telomeric region
GO:0001832 blastocyst growth
GO:0003684 damaged DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0007095 mitotic G2 DNA damage checkpoint signaling
GO:0008134 transcription factor binding
GO:0008283 cell population proliferation
GO:0016032 viral process
GO:0016605 PML body
GO:0030174 regulation of DNA-dependent DNA replication initiation
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0030870 Mre11 complex
GO:0031860 telomeric 3' overhang formation
GO:0031954 positive regulation of protein autophosphorylation
GO:0032206 positive regulation of telomere maintenance
GO:0032508 DNA duplex unwinding
GO:0033674 positive regulation of kinase activity
GO:0035861 site of double-strand break
GO:0042405 nuclear inclusion body
GO:0042770 signal transduction in response to DNA damage
GO:0045190 isotype switching
GO:0047485 protein N-terminus binding
GO:0050885 neuromuscular process controlling balance
GO:0051321 meiotic cell cycle
GO:0090656 t-circle formation
GO:0090737 telomere maintenance via telomere trimming
GO:0097193 intrinsic apoptotic signaling pathway
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1904354 negative regulation of telomere capping

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR000253 Forkhead-associated (FHA) domainDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR013908 DNA repair Nbs1, C-terminalDomainDomain
IPR016592 NibrinFamilyFamily
IPR032429 Nibrin, second BRCT domainDomainDomain
IPR036420 BRCT domain superfamilyFamilyHomologous superfamily
IPR040227 Nibrin-relatedFamilyFamily
IPR043014 Nibrin, second BRCT domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
NBN_HUMANH2AX_MOUSEBioGRID12792649 details