Entity Details

Primary name SRGP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75044
EntryNameSRGP2_HUMAN
FullNameSLIT-ROBO Rho GTPase-activating protein 2
TaxID9606
Evidenceevidence at protein level
Length1071
SequenceStatuscomplete
DateCreated2004-06-07
DateModified2021-06-02

Ontological Relatives

GenesSRGAP2

GO terms

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GOName
GO:0003363 lamellipodium assembly involved in ameboidal cell migration
GO:0005096 GTPase activator activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0014069 postsynaptic density
GO:0021816 extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
GO:0030027 lamellipodium
GO:0030336 negative regulation of cell migration
GO:0031267 small GTPase binding
GO:0034446 substrate adhesion-dependent cell spreading
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043547 positive regulation of GTPase activity
GO:0044327 dendritic spine head
GO:0045211 postsynaptic membrane
GO:0045335 phagocytic vesicle
GO:0046847 filopodium assembly
GO:0048812 neuron projection morphogenesis
GO:0051014 actin filament severing
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0060996 dendritic spine development
GO:2001223 negative regulation of neuron migration

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm
Cytoplasmic vesicle
Nucleus

Domains

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DomainNameCategoryType
IPR000198 Rho GTPase-activating protein domainDomainDomain
IPR001060 FCH domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008936 Rho GTPase activation proteinFamilyHomologous superfamily
IPR027267 AH/BAR domain superfamilyFamilyHomologous superfamily
IPR030252 SLIT-ROBO Rho GTPase-activating protein 2FamilyFamily
IPR031160 F-BAR domainDomainDomain
IPR035648 srGAP1/2/3, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
SRGP2_HUMANFMNL3_MOUSEUniProt21148482 details