Entity Details

Primary name P53_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP02340
EntryNameP53_MOUSE
FullNameCellular tumor antigen p53
TaxID10090
Evidenceevidence at protein level
Length390
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesTrp53

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000733 obsolete DNA strand renaturation
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001094 TFIID-class transcription factor complex binding
GO:0001216 DNA-binding transcription activator activity
GO:0001221 transcription coregulator binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001701 in utero embryonic development
GO:0001756 somitogenesis
GO:0001836 release of cytochrome c from mitochondria
GO:0002020 protease binding
GO:0002039 p53 binding
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002309 T cell proliferation involved in immune response
GO:0002326 B cell lineage commitment
GO:0002360 T cell lineage commitment
GO:0002687 positive regulation of leukocyte migration
GO:0002931 response to ischemia
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0003730 mRNA 3'-UTR binding
GO:0005507 copper ion binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005667 transcription regulator complex
GO:0005669 transcription factor TFIID complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005783 endoplasmic reticulum
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006289 nucleotide-excision repair
GO:0006302 double-strand break repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006606 protein import into nucleus
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006979 response to oxidative stress
GO:0006983 ER overload response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007369 gastrulation
GO:0007406 negative regulation of neuroblast proliferation
GO:0007417 central nervous system development
GO:0007507 heart development
GO:0007569 cell aging
GO:0007623 circadian rhythm
GO:0008022 protein C-terminus binding
GO:0008104 protein localization
GO:0008134 transcription factor binding
GO:0008156 negative regulation of DNA replication
GO:0008285 negative regulation of cell population proliferation
GO:0008340 determination of adult lifespan
GO:0009299 mRNA transcription
GO:0009303 rRNA transcription
GO:0009411 response to UV
GO:0009651 response to salt stress
GO:0009792 embryo development ending in birth or egg hatching
GO:0010038 response to metal ion
GO:0010165 response to X-ray
GO:0010224 response to UV-B
GO:0010332 response to gamma radiation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0016032 viral process
GO:0016363 nuclear matrix
GO:0016605 PML body
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0021549 cerebellum development
GO:0030308 negative regulation of cell growth
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030971 receptor tyrosine kinase binding
GO:0031000 response to caffeine
GO:0031065 positive regulation of histone deacetylation
GO:0031497 chromatin assembly
GO:0031571 mitotic G1 DNA damage checkpoint signaling
GO:0031625 ubiquitin protein ligase binding
GO:0032526 response to retinoic acid
GO:0032991 protein-containing complex
GO:0033077 T cell differentiation in thymus
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033552 response to vitamin B3
GO:0034103 regulation of tissue remodeling
GO:0034605 cellular response to heat
GO:0034613 cellular protein localization
GO:0034614 cellular response to reactive oxygen species
GO:0034644 cellular response to UV
GO:0035033 histone deacetylase regulator activity
GO:0035035 histone acetyltransferase binding
GO:0035264 multicellular organism growth
GO:0035690 cellular response to drug
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0035861 site of double-strand break
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0042060 wound healing
GO:0042127 regulation of cell population proliferation
GO:0042149 cellular response to glucose starvation
GO:0042493 response to drug
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0042826 histone deacetylase binding
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043153 entrainment of circadian clock by photoperiod
GO:0043200 response to amino acid
GO:0043504 mitochondrial DNA repair
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043523 regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0043621 protein self-association
GO:0045471 response to ethanol
GO:0045787 positive regulation of cell cycle
GO:0045861 negative regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0047485 protein N-terminus binding
GO:0048147 negative regulation of fibroblast proliferation
GO:0048512 circadian behavior
GO:0048539 bone marrow development
GO:0048568 embryonic organ development
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050821 protein stabilization
GO:0051087 chaperone binding
GO:0051262 protein tetramerization
GO:0051276 chromosome organization
GO:0051402 neuron apoptotic process
GO:0051453 regulation of intracellular pH
GO:0051721 protein phosphatase 2A binding
GO:0051726 regulation of cell cycle
GO:0051974 negative regulation of telomerase activity
GO:0055093 response to hyperoxia
GO:0060218 hematopoietic stem cell differentiation
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060411 cardiac septum morphogenesis
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0062100 positive regulation of programmed necrotic cell death
GO:0065003 protein-containing complex assembly
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070243 regulation of thymocyte apoptotic process
GO:0070245 positive regulation of thymocyte apoptotic process
GO:0070266 necroptotic process
GO:0071479 cellular response to ionizing radiation
GO:0071480 cellular response to gamma radiation
GO:0071494 cellular response to UV-C
GO:0072331 signal transduction by p53 class mediator
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0072717 cellular response to actinomycin D
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090343 positive regulation of cell aging
GO:0090399 replicative senescence
GO:0090403 oxidative stress-induced premature senescence
GO:0090575 RNA polymerase II transcription regulator complex
GO:0097252 oligodendrocyte apoptotic process
GO:0097371 MDM2/MDM4 family protein binding
GO:0097718 disordered domain specific binding
GO:1900119 positive regulation of execution phase of apoptosis
GO:1901525 negative regulation of mitophagy
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903205 regulation of hydrogen peroxide-induced cell death
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1904024 negative regulation of glucose catabolic process to lactate via pyruvate
GO:1905856 negative regulation of pentose-phosphate shunt
GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia
GO:1990248 regulation of transcription from RNA polymerase II promoter in response to DNA damage
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:1990841 promoter-specific chromatin binding
GO:2000269 regulation of fibroblast apoptotic process
GO:2000279 negative regulation of DNA biosynthetic process
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000772 regulation of cellular senescence
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum
Mitochondrion matrix
Nucleus

Domains

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DomainNameCategoryType
IPR002117 p53 tumour suppressor familyFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR010991 p53, tetramerisation domainDomainDomain
IPR011615 p53, DNA-binding domainDomainDomain
IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR013872 p53 transactivation domainDomainDomain
IPR036674 p53-like tetramerisation domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

117 interactions

InteractorPartnerSourcesPublicationsLink
P53_MOUSEHMGB1_MOUSEMINT11748221 details
P53_MOUSECHD3_HUMANIntAct15383276 details
P53_MOUSEPIAS4_HUMANIntAct11388671 15383276 details
P53_MOUSEP53_HUMANIntAct15383276 details
P53_MOUSEZHX1_HUMANIntAct15383276 details
P53_MOUSEEP300_MOUSEBioGRID, DIP, I2D, IntAct10706102 14555661 21057544 22666487 25117711 9194565 details
P53_MOUSEATM_HUMANIntAct17157788 details
P53_MOUSECHK2_HUMANIntAct17157788 details
P53_MOUSEPP1G_MOUSEBioGRID, IntAct17274640 details
P53_MOUSEMAPK5_MOUSEIntAct17254968 details
P53_MOUSEMDM2_MOUSEBioGRID, DIP, I2D, IntAct10205143 10706102 10982879 11953423 14555661 17086174 17936560 18309296 18359851 18566590 18695251 19556538 20697359 20818388 20832751 21183956 21738215 21857681 22216266 22666487 22805162 23580573 25117711 25732823 30545932 30578299 8058315 9732264 details
P53_MOUSESMRD1_MOUSEBioGRID, IntAct18303029 details
P53_MOUSEVRK1_HUMANIntAct10951572 details
P53_MOUSETOPRS_HUMANBioGRID, UniProt10415337 11842245 details
P53_MOUSEP53_MOUSEBioGRID, DIP11152481 16717092 20211142 25119037 8035799 details
P53_MOUSEZN292_MOUSEBioGRID, IntAct20211142 details
P53_MOUSETP53B_HUMANBioGRID16169070 details
P53_MOUSEKC1E_HUMANBioGRID9349507 details
P53_MOUSEMK08_HUMANBioGRID9393873 details
P53_MOUSEMK09_HUMANBioGRID9393873 details
P53_MOUSEMK10_HUMANBioGRID9393873 details
P53_MOUSEING4_HUMANBioGRID17325660 details
P53_MOUSEIKBA_MOUSEBioGRID20211142 details
P53_MOUSESIN3A_MOUSEBioGRID20211142 details
P53_MOUSEP63_MOUSEBioGRID20211142 23251530 details
P53_MOUSEP73_MOUSEBioGRID20211142 23251530 details
P53_MOUSEHABP4_HUMANBioGRID16455055 details
P53_MOUSEMDM2_HUMANBioGRID12771937 14555661 22991965 details
P53_MOUSEPIAS4_MOUSEBioGRID16816390 details
P53_MOUSEPIAS1_MOUSEBioGRID16816390 details
P53_MOUSEPIAS2_MOUSEBioGRID16816390 details
P53_MOUSEPAX3_MOUSEBioGRID22216266 details
P53_MOUSECDK2_MOUSEBioGRID16102793 details
P53_MOUSEITSN1_HUMANBioGRID22558309 details
P53_MOUSEUB2L3_HUMANBioGRID8144545 details
P53_MOUSESKIL_MOUSEBioGRID19745809 22805162 details
P53_MOUSESMYD1_MOUSEBioGRID12011100 details
P53_MOUSEZN363_MOUSEBioGRID24367557 details
P53_MOUSEAAPK1_HUMANBioGRID15866171 details
P53_MOUSEATM_MOUSEBioGRID21706008 details
P53_MOUSEBRNP1_MOUSEBioGRID25732823 details
P53_MOUSEKCMA1_MOUSEBioGRID25581503 details
P53_MOUSEHSP7C_HUMANBioGRID8940078 details
P53_MOUSEMELK_MOUSEBioGRID22532570 details
P53_MOUSEDMC1_MOUSEBioGRID14764457 details
P53_MOUSECBP_MOUSEDIP9194565 details
P53_MOUSEEP400_MOUSEDIP9194565 details
P53_MOUSEB2CL1_MOUSEBioGRID, IntAct14963330 16151013 30683842 details
P53_MOUSEB2CL1_HUMANIntAct16151013 details
P53_MOUSEHS71L_MOUSEMINT10637512 details
P53_MOUSEUBB_MOUSEDIP, MINT18309296 21730132 21857681 details
P53_MOUSEUBC_MOUSEDIP, MINT18309296 21730132 21857681 details
P53_MOUSERS27A_MOUSEDIP, MINT18309296 21730132 21857681 details
P53_MOUSERL40_MOUSEDIP, MINT18309296 21730132 21857681 details
P53_MOUSEBARD1_MOUSEBioGRID, UniProt11779501 15782130 details
P53_MOUSEEP300_HUMANIntAct18612383 details
P53_MOUSEDAXX_MOUSEBioGRID, MINT15364927 18566590 details
P53_MOUSEAPBB1_MOUSEMINT19796171 details
P53_MOUSEMDM4_MOUSEBioGRID, DIP, I2D, IntAct11953423 19573810 20697359 21730132 25981963 details
P53_MOUSEMK14_MOUSEBioGRID, MINT21050851 details
P53_MOUSECDN1A_MOUSEBioGRID, I2D, IntAct21057544 22666487 23410974 details
P53_MOUSEPIN1_HUMANIntAct21741598 details
P53_MOUSEPIN1_MOUSEIntAct21741598 details
P53_MOUSEPPIF_MOUSEIntAct22726440 details
P53_MOUSESODM_MOUSEI2D21909133 details
P53_MOUSEDPOG1_MOUSEI2D21909133 details
P53_MOUSETWST1_MOUSEBioGRID, IntAct22975381 details
P53_MOUSEPTEN_MOUSEBioGRID, MINT18332125 23123091 details
P53_MOUSEGFI1_MOUSEIntAct23410974 details
P53_MOUSEBBC3_MOUSEBioGRID, IntAct23410974 24553927 details
P53_MOUSEIASPP_MOUSEIntAct23623661 details
P53_MOUSEYBOX1_MOUSEIntAct24788519 details
P53_MOUSEBACH1_MOUSEDIP19011633 details
P53_MOUSETIF1A_MOUSEDIP19556538 details
P53_MOUSERUVB1_MOUSEIntAct25857266 details
P53_MOUSEDDB1_MOUSEBioGRID17967871 details
P53_MOUSEUBE2N_MOUSEBioGRID17000756 details
P53_MOUSEPRKDC_MOUSEBioGRID15792956 details
P53_MOUSEKMT2E_MOUSEBioGRID21423215 details
P53_MOUSENPM_HUMANBioGRID17277230 details
P53_MOUSENPM_MOUSEBioGRID17277230 details
P53_MOUSESIR1_MOUSEBioGRID20157588 details
P53_MOUSESP1_MOUSEBioGRID20157588 details
P53_MOUSEFAK2_MOUSEBioGRID19880522 details
P53_MOUSESMCA4_MOUSEBioGRID18303029 details
P53_MOUSEHUWE1_MOUSEBioGRID22754359 details
P53_MOUSEMK08_MOUSEBioGRID10706102 15580310 9732264 details
P53_MOUSENUMB_HUMANBioGRID9632782 details
P53_MOUSECCNG1_MOUSEBioGRID11983168 details
P53_MOUSEPARK7_MOUSEBioGRID19680261 details
P53_MOUSEZBT7C_MOUSEBioGRID22253232 details
P53_MOUSEGSK3B_MOUSEBioGRID21738215 details
P53_MOUSETOPRS_MOUSEBioGRID15735665 details
P53_MOUSEHS71B_MOUSEBioGRID23251530 details
P53_MOUSECDN2A_MOUSEBioGRID10706102 15989966 9653180 details
P53_MOUSEARF_MOUSEBioGRID10706102 15989966 9653180 details
P53_MOUSEAXIN1_MOUSEBioGRID15526030 details
P53_MOUSEHIPK2_MOUSEBioGRID15526030 details
P53_MOUSEWWOX_MOUSEBioGRID15580310 details
P53_MOUSERL11_MOUSEBioGRID15989966 details
P53_MOUSERS26_MOUSEBioGRID23728348 details
P53_MOUSEHERC2_MOUSEBioGRID24722987 details
P53_MOUSENECD_MOUSEBioGRID24911587 details
P53_MOUSERN128_MOUSEBioGRID23370271 details
P53_MOUSEREV1_MOUSEBioGRID25614517 details
P53_MOUSEDAPK1_MOUSEBioGRID25139875 details
P53_MOUSEPRKN_MOUSEBioGRID28395174 details
P53_MOUSECUL7_MOUSEBioGRID24793696 details
P53_MOUSEVEGFA_MOUSEBioGRID23449391 details
P53_MOUSEPSD10_MOUSEBioGRID30109252 details
P53_MOUSERAD51_MOUSEBioGRID14764457 details
P53_MOUSEUBP7_MOUSEBioGRID30545932 details
P53_MOUSEKLF4_MOUSEBioGRID30578299 details
P53_MOUSEIRS1_HUMANBioGRID30578299 details
P53_MOUSEIRS1_MOUSEBioGRID30578299 details
P53_MOUSEBCL2_MOUSEBioGRID30683842 details
P53_MOUSETMUB1_MOUSEBioGRID31867855 details