Entity Details

Primary name ULK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75385
EntryNameULK1_HUMAN
FullNameSerine/threonine-protein kinase ULK1
TaxID9606
Evidenceevidence at protein level
Length1050
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesULK1

GO terms

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GOName
GO:0000045 autophagosome assembly
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005776 autophagosome
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006914 autophagy
GO:0007165 signal transduction
GO:0008104 protein localization
GO:0010508 positive regulation of autophagy
GO:0016236 macroautophagy
GO:0016241 regulation of macroautophagy
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030424 axon
GO:0031102 neuron projection regeneration
GO:0031175 neuron projection development
GO:0031267 small GTPase binding
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031669 cellular response to nutrient levels
GO:0034045 phagophore assembly site membrane
GO:0042594 response to starvation
GO:0042802 identical protein binding
GO:0044877 protein-containing complex binding
GO:0046777 protein autophosphorylation
GO:0048675 axon extension
GO:0051020 GTPase binding
GO:0055037 recycling endosome
GO:0075044 positive regulation by symbiont of host autophagy
GO:0097629 extrinsic component of omegasome membrane
GO:0097632 extrinsic component of phagophore assembly site membrane
GO:0097635 extrinsic component of autophagosome membrane
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1990316 Atg1/ULK1 kinase complex
GO:2000786 positive regulation of autophagosome assembly

Subcellular Location

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Subcellular Location
Cytoplasm
Preautophagosomal structure

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016237 Serine/threonine-protein kinase, Ulk1/Ulk2FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR022708 Serine/threonine-protein kinase, C-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
ULK1_HUMANSQSTM_MOUSEBioGRID31362587 details