Entity Details

Primary name ERN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75460
EntryNameERN1_HUMAN
FullNameSerine/threonine-protein kinase/endoribonuclease IRE1
TaxID9606
Evidenceevidence at protein level
Length977
SequenceStatuscomplete
DateCreated2004-08-16
DateModified2021-06-02

Ontological Relatives

GenesERN1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001935 endothelial cell proliferation
GO:0004521 endoribonuclease activity
GO:0004674 protein serine/threonine kinase activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005524 ATP binding
GO:0005637 nuclear inner membrane
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006379 mRNA cleavage
GO:0006402 mRNA catabolic process
GO:0006468 protein phosphorylation
GO:0007257 obsolete activation of JUN kinase activity
GO:0016241 regulation of macroautophagy
GO:0019899 enzyme binding
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0030544 Hsp70 protein binding
GO:0033120 positive regulation of RNA splicing
GO:0034620 cellular response to unfolded protein
GO:0034976 response to endoplasmic reticulum stress
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036289 peptidyl-serine autophosphorylation
GO:0036498 IRE1-mediated unfolded protein response
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043531 ADP binding
GO:0046777 protein autophosphorylation
GO:0051082 unfolded protein binding
GO:0051879 Hsp90 protein binding
GO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070301 cellular response to hydrogen peroxide
GO:0071333 cellular response to glucose stimulus
GO:0098787 mRNA cleavage involved in mRNA processing
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1901142 insulin metabolic process
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1990332 Ire1 complex
GO:1990579 peptidyl-serine trans-autophosphorylation
GO:1990597 AIP1-IRE1 complex
GO:1990604 IRE1-TRAF2-ASK1 complex
GO:1990630 IRE1-RACK1-PP2A complex

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR010513 KEN domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011047 Quinoprotein alcohol dehydrogenase-like superfamilyFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR018391 Pyrrolo-quinoline quinone beta-propeller repeatRepeatRepeat
IPR038357 KEN domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB07382 N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamineDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule