Entity Details

Primary name PPM1B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75688
EntryNamePPM1B_HUMAN
FullNameProtein phosphatase 1B
TaxID9606
Evidenceevidence at protein level
Length479
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesPPM1B

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0004722 protein serine/threonine phosphatase activity
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0006470 protein dephosphorylation
GO:0006499 N-terminal protein myristoylation
GO:0016020 membrane
GO:0030145 manganese ion binding
GO:0032688 negative regulation of interferon-beta production
GO:0035970 peptidyl-threonine dephosphorylation
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050687 negative regulation of defense response to virus
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:1901223 negative regulation of NIK/NF-kappaB signaling

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR000222 PPM-type phosphatase, divalent cation bindingSiteBinding site
IPR001932 PPM-type phosphatase domainDomainDomain
IPR012911 Protein serine/threonine phosphatase 2C, C-terminalDomainDomain
IPR036457 PPM-type phosphatase domain superfamilyFamilyHomologous superfamily
IPR036580 Phosphatase 2C, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PPM1B_HUMANSMUF2_MOUSEBioGRID, IntAct19379695 details