Entity Details

Primary name BCAR3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75815
EntryNameBCAR3_HUMAN
FullNameBreast cancer anti-estrogen resistance protein 3
TaxID9606
Evidenceevidence at protein level
Length825
SequenceStatuscomplete
DateCreated2006-04-04
DateModified2021-06-02

Ontological Relatives

GenesBCAR3

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0002089 lens morphogenesis in camera-type eye
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0008286 insulin receptor signaling pathway
GO:0016020 membrane
GO:0019900 kinase binding
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042493 response to drug
GO:0043410 positive regulation of MAPK cascade
GO:0043547 positive regulation of GTPase activity
GO:0045740 positive regulation of DNA replication
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0086100 endothelin receptor signaling pathway

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domainDomainDomain
IPR023578 Ras guanine nucleotide exchange factor domain superfamilyFamilyHomologous superfamily
IPR028849 Breast cancer anti-estrogen resistance protein 3FamilyFamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamilyFamilyHomologous superfamily
IPR044102 SHEP1/BCAR3/NSP1, SH2 domainDomainDomain

Diseases

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Interactions

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