Entity Details

Primary name IDHC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75874
EntryNameIDHC_HUMAN
FullNameIsocitrate dehydrogenase [NADP] cytoplasmic
TaxID9606
Evidenceevidence at protein level
Length414
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesIDH1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0006103 2-oxoglutarate metabolic process
GO:0006739 NADP metabolic process
GO:0006740 NADPH regeneration
GO:0006749 glutathione metabolic process
GO:0006979 response to oxidative stress
GO:0008104 protein localization
GO:0008585 female gonad development
GO:0034774 secretory granule lumen
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043312 neutrophil degranulation
GO:0045296 cadherin binding
GO:0048545 response to steroid hormone
GO:0050661 NADP binding
GO:0051287 NAD binding
GO:0060696 regulation of phospholipid catabolic process
GO:0070062 extracellular exosome
GO:0071071 regulation of phospholipid biosynthetic process
GO:1904724 tertiary granule lumen
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Cytoplasm
Peroxisome

Domains

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DomainNameCategoryType
IPR004790 Isocitrate dehydrogenase NADP-dependentFamilyFamily
IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved siteSiteConserved site
IPR024084 Isopropylmalate dehydrogenase-like domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01727 Isocitric AcidDrugbanksmall molecule
DB03461 Nicotinamide adenine dinucleotide phosphateDrugbanksmall molecule
DB09374 Indocyanine green acid formSwissprotsmall molecule
DB14568 IvosidenibDrugbanksmall molecule

Interactions

0 interactions

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