Entity Details

Primary name PIAS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75928
EntryNamePIAS2_HUMAN
FullNameE3 SUMO-protein ligase PIAS2
TaxID9606
Evidenceevidence at protein level
Length621
SequenceStatuscomplete
DateCreated2004-12-07
DateModified2021-06-02

Ontological Relatives

GenesPIAS2

GO terms

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GOName
GO:0003677 DNA binding
GO:0003712 transcription coregulator activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0016605 PML body
GO:0016607 nuclear speck
GO:0016925 protein sumoylation
GO:0019789 SUMO transferase activity
GO:0031625 ubiquitin protein ligase binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0061665 SUMO ligase activity

Subcellular Location

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Subcellular Location
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR003034 SAP domainDomainDomain
IPR004181 Zinc finger, MIZ-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR023321 PINIT domainDomainDomain
IPR027228 E3 SUMO-protein ligase PIAS2FamilyFamily
IPR036361 SAP domain superfamilyFamilyHomologous superfamily
IPR038654 PINIT domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PIAS2_HUMANIKZF1_MOUSEIntAct15767674 details