Entity Details

Primary name RNF8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO76064
EntryNameRNF8_HUMAN
FullNameE3 ubiquitin-protein ligase RNF8
TaxID9606
Evidenceevidence at protein level
Length485
SequenceStatuscomplete
DateCreated2002-06-06
DateModified2021-06-02

Ontological Relatives

GenesRNF8

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0000781 chromosome, telomeric region
GO:0003682 chromatin binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007286 spermatid development
GO:0008270 zinc ion binding
GO:0010212 response to ionizing radiation
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0030496 midbody
GO:0031625 ubiquitin protein ligase binding
GO:0033522 histone H2A ubiquitination
GO:0033523 histone H2B ubiquitination
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
GO:0035093 spermatogenesis, exchange of chromosomal proteins
GO:0035861 site of double-strand break
GO:0036297 interstrand cross-link repair
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043130 ubiquitin binding
GO:0043486 histone exchange
GO:0045190 isotype switching
GO:0045739 positive regulation of DNA repair
GO:0051301 cell division
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0070534 protein K63-linked ubiquitination
GO:0070535 histone H2A K63-linked ubiquitination
GO:0070936 protein K48-linked ubiquitination

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Midbody
Nucleus

Domains

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DomainNameCategoryType
IPR000253 Forkhead-associated (FHA) domainDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017335 E3 ubiquitin-protein ligase RNF8FamilyFamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
RNF8_HUMANH2AX_MOUSEIntAct18001825 details