Entity Details

Primary name PDE5A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO76074
EntryNamePDE5A_HUMAN
FullNamecGMP-specific 3',5'-cyclic phosphodiesterase
TaxID9606
Evidenceevidence at protein level
Length875
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesPDE5A

GO terms

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GOName
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0030553 cGMP binding
GO:0046069 cGMP catabolic process
GO:0046872 metal ion binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity

Subcellular Location

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Domains

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DomainNameCategoryType
IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domainDomainDomain
IPR003018 GAF domainDomainDomain
IPR003607 HD/PDEase domainDomainDomain
IPR023088 3'5'-cyclic nucleotide phosphodiesteraseFamilyFamily
IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved siteSiteConserved site
IPR029016 GAF-like domain superfamilyFamilyHomologous superfamily
IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule
DB00203 SildenafilDrugbanksmall molecule
DB00277 TheophyllineDrugbanksmall molecule
DB00820 TadalafilDrugbanksmall molecule
DB00862 VardenafilDrugbanksmall molecule
DB00975 DipyridamoleDrugbanksmall molecule
DB01972 Guanosine-5'-MonophosphateDrugbanksmall molecule
DB03597 gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycineDrugbanksmall molecule
DB05415 OSI-461Drugbanksmall molecule
DB06237 AvanafilDrugbanksmall molecule
DB06246 ExisulindDrugbanksmall molecule
DB06267 UdenafilDrugbanksmall molecule
DB07954 3-isobutyl-1-methyl-7H-xanthineDrugbanksmall molecule
DB08729 5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamideDrugbanksmall molecule
DB09282 MolsidomineDrugbanksmall molecule
DB09283 TrapidilDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink