Entity Details

Primary name TNKS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95271
EntryNameTNKS1_HUMAN
FullNamePoly [ADP-ribose] polymerase tankyrase-1
TaxID9606
Evidenceevidence at protein level
Length1327
SequenceStatuscomplete
DateCreated2002-03-27
DateModified2021-06-02

Ontological Relatives

GenesTNKS

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0000242 pericentriolar material
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0006471 protein ADP-ribosylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051973 positive regulation of telomerase activity
GO:0070213 protein auto-ADP-ribosylation
GO:0097431 mitotic spindle pole
GO:1904355 positive regulation of telomere capping
GO:0008270 zinc ion binding
GO:0016604 nuclear body
GO:0042393 histone binding
GO:0051028 mRNA transport
GO:1904357 negative regulation of telomere maintenance via telomere lengthening
GO:0000139 Golgi membrane
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0007052 mitotic spindle organization
GO:0015031 protein transport
GO:0016055 Wnt signaling pathway
GO:0018105 peptidyl-serine phosphorylation
GO:0070198 protein localization to chromosome, telomeric region
GO:0070212 protein poly-ADP-ribosylation
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1904908 negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005829 cytosol
GO:0031670 cellular response to nutrient
GO:0031965 nuclear membrane
GO:0032210 regulation of telomere maintenance via telomerase
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0051225 spindle assembly
GO:0051301 cell division
GO:1904743 negative regulation of telomeric DNA binding
GO:1990404 protein ADP-ribosylase activity

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Golgi apparatus membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001660 Sterile alpha motif domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR012317 Poly(ADP-ribose) polymerase, catalytic domainDomainDomain
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR028731 Poly [ADP-ribose] polymerase tankyrase-1FamilyFamily
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
TNKS1_HUMANAXIN1_MOUSEDIP19759537 details
TNKS1_HUMAN3BP2_MOUSEIntAct22153076 details