Entity Details

Primary name PARN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95453
EntryNamePARN_HUMAN
FullNamePoly(A)-specific ribonuclease PARN
TaxID9606
Evidenceevidence at protein level
Length639
SequenceStatuscomplete
DateCreated2005-03-01
DateModified2021-06-02

Ontological Relatives

GenesPARN

GO terms

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GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000495 box H/ACA RNA 3'-end processing
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0004518 nuclease activity
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007292 female gamete generation
GO:0009451 RNA modification
GO:0010587 miRNA catabolic process
GO:0016607 nuclear speck
GO:0019901 protein kinase binding
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0043169 cation binding
GO:0043488 regulation of mRNA stability
GO:0046872 metal ion binding
GO:0051973 positive regulation of telomerase activity
GO:0070034 telomerase RNA binding
GO:0071051 polyadenylation-dependent snoRNA 3'-end processing
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:0090669 telomerase RNA stabilization
GO:0110008 ncRNA deadenylation
GO:1904872 regulation of telomerase RNA localization to Cajal body

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001374 R3H domainDomainDomain
IPR006941 Ribonuclease CAF1FamilyFamily
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR012677 Nucleotide-binding alpha-beta plait domain superfamilyFamilyHomologous superfamily
IPR014789 Poly(A)-specific ribonuclease, RNA-bindingDomainDomain
IPR034042 PARN, R3H domainDomainDomain
IPR035979 RNA-binding domain superfamilyFamilyHomologous superfamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily
IPR036867 R3H domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

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