Entity Details

Primary name ABCA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95477
EntryNameABCA1_HUMAN
FullNamePhospholipid-transporting ATPase ABCA1
TaxID9606
Evidenceevidence at protein level
Length2261
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesABCA1

GO terms

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GOName
GO:0005102 signaling receptor binding
GO:0005319 lipid transporter activity
GO:0005524 ATP binding
GO:0005548 phospholipid transporter activity
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006869 lipid transport
GO:0007040 lysosome organization
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0008203 cholesterol metabolic process
GO:0008320 protein transmembrane transporter activity
GO:0009306 protein secretion
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010875 positive regulation of cholesterol efflux
GO:0010887 negative regulation of cholesterol storage
GO:0015485 cholesterol binding
GO:0016197 endosomal transport
GO:0019222 regulation of metabolic process
GO:0019905 syntaxin binding
GO:0023061 signal release
GO:0030139 endocytic vesicle
GO:0030522 intracellular receptor signaling pathway
GO:0031210 phosphatidylcholine binding
GO:0031267 small GTPase binding
GO:0032367 intracellular cholesterol transport
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034185 apolipoprotein binding
GO:0034186 apolipoprotein A-I binding
GO:0034188 apolipoprotein A-I receptor activity
GO:0034380 high-density lipoprotein particle assembly
GO:0034616 response to laminar fluid shear stress
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042632 cholesterol homeostasis
GO:0043231 intracellular membrane-bounded organelle
GO:0043691 reverse cholesterol transport
GO:0045121 membrane raft
GO:0045332 phospholipid translocation
GO:0045335 phagocytic vesicle
GO:0046623 sphingolipid floppase activity
GO:0048471 perinuclear region of cytoplasm
GO:0051117 ATPase binding
GO:0055091 phospholipid homeostasis
GO:0060155 platelet dense granule organization
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0071806 protein transmembrane transport
GO:0090107 regulation of high-density lipoprotein particle assembly
GO:0090108 positive regulation of high-density lipoprotein particle assembly
GO:0090554 phosphatidylcholine floppase activity
GO:0090556 phosphatidylserine floppase activity
GO:0097708 intracellular vesicle
GO:0120020 cholesterol transfer activity
GO:0140115 export across plasma membrane
GO:0140328 floppase activity

Subcellular Location

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Subcellular Location
Cell membrane
Endosome

Domains

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DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR026082 ABC transporter AFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030365 ATP-binding cassette subfamily A member 1FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00163 Vitamin EDrugbanksmall molecule
DB00171 ATPDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB01016 GlyburideDrugbanksmall molecule
DB01599 ProbucolDrugbanksmall molecule
DB11635 TocofersolanDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
ABCA1_HUMANLIN7C_MOUSEIntAct16192269 details