Entity Details

Primary name IL2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP04351
EntryNameIL2_MOUSE
FullNameInterleukin-2
TaxID10090
Evidenceevidence at protein level
Length169
SequenceStatuscomplete
DateCreated1987-03-20
DateModified2021-06-02

Ontological Relatives

GenesIl2

GO terms

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GOName
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0002250 adaptive immune response
GO:0002366 leukocyte activation involved in immune response
GO:0002639 positive regulation of immunoglobulin production
GO:0002903 negative regulation of B cell apoptotic process
GO:0005125 cytokine activity
GO:0005134 interleukin-2 receptor binding
GO:0005615 extracellular space
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
GO:0008083 growth factor activity
GO:0010467 gene expression
GO:0030246 carbohydrate binding
GO:0030890 positive regulation of B cell proliferation
GO:0031851 kappa-type opioid receptor binding
GO:0032729 positive regulation of interferon-gamma production
GO:0032740 positive regulation of interleukin-17 production
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043208 glycosphingolipid binding
GO:0045471 response to ethanol
GO:0045582 positive regulation of T cell differentiation
GO:0045591 positive regulation of regulatory T cell differentiation
GO:0045822 negative regulation of heart contraction
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046013 regulation of T cell homeostatic proliferation
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050728 negative regulation of inflammatory response
GO:0060999 positive regulation of dendritic spine development
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1900100 positive regulation of plasma cell differentiation
GO:2000320 negative regulation of T-helper 17 cell differentiation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000779 Interleukin-2FamilyFamily
IPR009079 Four-helical cytokine-like, coreFamilyHomologous superfamily
IPR030477 Interleukin-2, conserved siteSiteConserved site

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
IL2_MOUSEIL2RG_MOUSEUniProt8266076 details