Entity Details

Primary name HG2A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP04441
EntryNameHG2A_MOUSE
FullNameH-2 class II histocompatibility antigen gamma chain
TaxID10090
Evidenceevidence at protein level
Length279
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesCd74

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001516 prostaglandin biosynthetic process
GO:0001540 amyloid-beta binding
GO:0001934 positive regulation of protein phosphorylation
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0002286 T cell activation involved in immune response
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0002792 negative regulation of peptide secretion
GO:0002821 positive regulation of adaptive immune response
GO:0002830 positive regulation of type 2 immune response
GO:0002906 negative regulation of mature B cell apoptotic process
GO:0004896 cytokine receptor activity
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0005773 vacuole
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006886 intracellular protein transport
GO:0006952 defense response
GO:0008283 cell population proliferation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0016021 integral component of membrane
GO:0016064 immunoglobulin mediated immune response
GO:0019882 antigen processing and presentation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019955 cytokine binding
GO:0023026 MHC class II protein complex binding
GO:0030336 negative regulation of cell migration
GO:0030890 positive regulation of B cell proliferation
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0032722 positive regulation of chemokine production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032991 protein-containing complex
GO:0033674 positive regulation of kinase activity
GO:0034341 response to interferon-gamma
GO:0035691 macrophage migration inhibitory factor signaling pathway
GO:0035692 macrophage migration inhibitory factor receptor complex
GO:0035693 NOS2-CD74 complex
GO:0035718 macrophage migration inhibitory factor binding
GO:0042289 MHC class II protein binding
GO:0042609 CD4 receptor binding
GO:0042658 MHC class II protein binding, via antigen binding groove
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410 positive regulation of MAPK cascade
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044183 protein folding chaperone
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0045089 positive regulation of innate immune response
GO:0045581 negative regulation of T cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045657 positive regulation of monocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046597 negative regulation of viral entry into host cell
GO:0046598 positive regulation of viral entry into host cell
GO:0048146 positive regulation of fibroblast proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050821 protein stabilization
GO:0050998 nitric-oxide synthase binding
GO:0051085 chaperone cofactor-dependent protein refolding
GO:0060907 positive regulation of macrophage cytokine production
GO:0065003 protein-containing complex assembly
GO:0070206 protein trimerization
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090023 positive regulation of neutrophil chemotaxis
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
GO:2000448 positive regulation of macrophage migration inhibitory factor signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane
Endosome
Golgi apparatus
Late endosome
Lysosome

Domains

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DomainNameCategoryType
IPR000716 Thyroglobulin type-1DomainDomain
IPR011988 MHC class II-associated invariant chain, trimerisationDomainDomain
IPR015386 MHC class II-associated invariant chain/CLIP, MHC II-interactingDomainDomain
IPR022339 MHC class II-associated invariant chainFamilyFamily
IPR036613 MHC class II-associated invariant chain, trimerisation domain superfamilyFamilyHomologous superfamily
IPR036857 Thyroglobulin type-1 superfamilyFamilyHomologous superfamily
IPR043530 HLA class II histocompatibility antigen, gamma subunitFamilyFamily

Diseases

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Interactions

4 interactions