Entity Details

Primary name AP2A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95782
EntryNameAP2A1_HUMAN
FullNameAP-2 complex subunit alpha-1
TaxID9606
Evidenceevidence at protein level
Length977
SequenceStatuscomplete
DateCreated2001-01-24
DateModified2021-06-02

Ontological Relatives

GenesAP2A1

GO terms

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GOName
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006886 intracellular protein transport
GO:0006895 Golgi to endosome transport
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0008022 protein C-terminus binding
GO:0010976 positive regulation of neuron projection development
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019901 protein kinase binding
GO:0030122 AP-2 adaptor complex
GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0032433 filopodium tip
GO:0032802 low-density lipoprotein particle receptor catabolic process
GO:0034383 low-density lipoprotein particle clearance
GO:0035615 clathrin adaptor activity
GO:0036020 endolysosome membrane
GO:0044877 protein-containing complex binding
GO:0045334 clathrin-coated endocytic vesicle
GO:0048013 ephrin receptor signaling pathway
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0050690 regulation of defense response to virus by virus
GO:0050750 low-density lipoprotein particle receptor binding
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061024 membrane organization
GO:0072583 clathrin-dependent endocytosis
GO:0140312 cargo adaptor activity
GO:1900126 negative regulation of hyaluronan biosynthetic process

Subcellular Location

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Subcellular Location
Cell membrane
Membrane

Domains

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DomainNameCategoryType
IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminalDomainDomain
IPR003164 Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomainDomainDomain
IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomainDomainDomain
IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomainFamilyHomologous superfamily
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR012295 TBP domain superfamilyFamilyHomologous superfamily
IPR013041 Clathrin adaptor, appendage, Ig-like subdomain superfamilyFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR017104 Adaptor protein complex AP-2, alpha subunitFamilyFamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
AP2A1_HUMANEPS15_MOUSEBioGRID12057195 details