Entity Details

Primary name FBLN4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95967
EntryNameFBLN4_HUMAN
FullNameEGF-containing fibulin-like extracellular matrix protein 2
TaxID9606
Evidenceevidence at protein level
Length443
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesEFEMP2

GO terms

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GOName
GO:0001527 microfibril
GO:0005201 extracellular matrix structural constituent
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0008201 heparin binding
GO:0031012 extracellular matrix
GO:0035904 aorta development
GO:0042803 protein homodimerization activity
GO:0048251 elastic fiber assembly
GO:0060414 aorta smooth muscle tissue morphogenesis
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0071953 elastic fiber
GO:0097084 vascular associated smooth muscle cell development
GO:1903561 extracellular vesicle
GO:1904026 regulation of collagen fibril organization
GO:1904028 positive regulation of collagen fibril organization
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
GO:1904831 positive regulation of aortic smooth muscle cell differentiation
GO:1905609 positive regulation of smooth muscle cell-matrix adhesion

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR026823 Complement Clr-like EGF domainDomainDomain
IPR026824 EGF-containing fibulin-like extracellular matrix protein 2FamilyFamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
FBLN4_HUMANHXA1_MOUSEIntAct23088713 details