Entity Details

Primary name PRIO_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP04925
EntryNamePRIO_MOUSE
FullNameMajor prion protein
TaxID10090
Evidenceevidence at protein level
Length254
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesPrnp

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001933 negative regulation of protein phosphorylation
GO:0002020 protease binding
GO:0005507 copper ion binding
GO:0005509 calcium ion binding
GO:0005521 lamin binding
GO:0005539 glycosaminoglycan binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006139 nucleobase-containing compound metabolic process
GO:0006878 cellular copper ion homeostasis
GO:0006979 response to oxidative stress
GO:0007611 learning or memory
GO:0008017 microtubule binding
GO:0009986 cell surface
GO:0010942 positive regulation of cell death
GO:0014069 postsynaptic density
GO:0015631 tubulin binding
GO:0016020 membrane
GO:0016234 inclusion body
GO:0019828 aspartic-type endopeptidase inhibitor activity
GO:0031225 anchored component of membrane
GO:0031648 protein destabilization
GO:0031802 type 5 metabotropic glutamate receptor binding
GO:0031965 nuclear membrane
GO:0032147 activation of protein kinase activity
GO:0032689 negative regulation of interferon-gamma production
GO:0032700 negative regulation of interleukin-17 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032880 regulation of protein localization
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0035690 cellular response to drug
GO:0038023 signaling receptor activity
GO:0042802 identical protein binding
GO:0043008 ATP-dependent protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043086 negative regulation of catalytic activity
GO:0043195 terminal bouton
GO:0043231 intracellular membrane-bounded organelle
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043525 positive regulation of neuron apoptotic process
GO:0044325 transmembrane transporter binding
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0046007 negative regulation of activated T cell proliferation
GO:0046686 response to cadmium ion
GO:0046688 response to copper ion
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0051087 chaperone binding
GO:0051260 protein homooligomerization
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0071280 cellular response to copper ion
GO:0090314 positive regulation of protein targeting to membrane
GO:0090647 modulation of age-related behavioral decline
GO:1900272 negative regulation of long-term synaptic potentiation
GO:1900449 regulation of glutamate receptor signaling pathway
GO:1901216 positive regulation of neuron death
GO:1901379 regulation of potassium ion transmembrane transport
GO:1902430 negative regulation of amyloid-beta formation
GO:1902938 regulation of intracellular calcium activated chloride channel activity
GO:1902951 negative regulation of dendritic spine maintenance
GO:1902992 negative regulation of amyloid precursor protein catabolic process
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903135 cupric ion binding
GO:1903136 cuprous ion binding
GO:1904645 response to amyloid-beta
GO:1904646 cellular response to amyloid-beta
GO:1905664 regulation of calcium ion import across plasma membrane
GO:1990535 neuron projection maintenance

Subcellular Location

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Subcellular Location
Cell membrane
Golgi apparatus

Domains

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DomainNameCategoryType
IPR000817 Prion proteinFamilyFamily
IPR022416 Prion/Doppel protein, beta-ribbon domainDomainDomain
IPR025860 Major prion protein N-terminal domainDomainDomain
IPR036924 Prion/Doppel beta-ribbon domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

49 interactions

InteractorPartnerSourcesPublicationsLink
PRIO_MOUSEROA2_HUMANIntAct16294306 details
PRIO_MOUSEGRB2_MOUSEBioGRID, MINT11571277 15301538 details
PRIO_MOUSEPRIO_MOUSEDIP, MINT, UniProt19805070 20345906 21041683 21441913 22449963 22854022 23892077 details
PRIO_MOUSENCAM1_HUMANBioGRID27535221 details
PRIO_MOUSEAPOE_MOUSEBioGRID, MINT15146195 32325033 details
PRIO_MOUSENCAM1_MOUSEBioGRID, MINT15146195 32325033 details
PRIO_MOUSEDPP6_MOUSEBioGRID, MINT15146195 24225951 32325033 details
PRIO_MOUSENCAM2_MOUSEBioGRID, MINT15146195 32325033 details
PRIO_MOUSECNTN1_MOUSEBioGRID, MINT15146195 32325033 details
PRIO_MOUSEMAG_MOUSEBioGRID, MINT15146195 32325033 details
PRIO_MOUSEDYN1_MOUSEBioGRID, MINT15146195 details
PRIO_MOUSEMOG_MOUSEBioGRID, MINT15146195 details
PRIO_MOUSELSAMP_MOUSEMINT15146195 details
PRIO_MOUSEAPLP1_MOUSEMINT15146195 details
PRIO_MOUSECLUS_MOUSEBioGRID, MINT15146195 32325033 details
PRIO_MOUSENTRI_MOUSEMINT15146195 details
PRIO_MOUSENECT1_MOUSEBioGRID, MINT15146195 32325033 details
PRIO_MOUSEADA23_MOUSEBioGRID, MINT15146195 details
PRIO_MOUSEPDIA1_MOUSEBioGRID, MINT15146195 details
PRIO_MOUSEL1CAM_MOUSEMINT15146195 details
PRIO_MOUSESPRL1_MOUSEBioGRID, MINT15146195 32325033 details
PRIO_MOUSECSTN1_MOUSEBioGRID, MINT15146195 32325033 details
PRIO_MOUSEAPLP2_MOUSEBioGRID, MINT15146195 32325033 details
PRIO_MOUSEBIP_MOUSEBioGRID, MINT15146195 32325033 details
PRIO_MOUSEAPBB1_MOUSEBioGRID, MINT15146195 details
PRIO_MOUSEA4_MOUSEBioGRID, IntAct15146195 17934213 details
PRIO_MOUSEPSMD6_MOUSEMINT21743439 details
PRIO_MOUSEPRS7_MOUSEMINT21743439 details
PRIO_MOUSEPRIO_HUMANMINT22285492 details
PRIO_MOUSEGRM5_MOUSEIntAct24012003 details
PRIO_MOUSEPRND_MOUSEIntAct16766127 details
PRIO_MOUSECA2D1_MOUSEIntAct22542184 details
PRIO_MOUSEBACE1_HUMANDIP17573534 details
PRIO_MOUSEAT2B2_MOUSEBioGRID15146195 details
PRIO_MOUSEIGSF8_MOUSEBioGRID15146195 details
PRIO_MOUSECADM3_MOUSEBioGRID15146195 details
PRIO_MOUSE1433Z_MOUSEBioGRID15146195 details
PRIO_MOUSE1433E_MOUSEBioGRID15146195 details
PRIO_MOUSEAT1A3_MOUSEBioGRID15146195 details
PRIO_MOUSEAT1A1_MOUSEBioGRID15146195 details
PRIO_MOUSEAT1B1_MOUSEBioGRID15146195 details
PRIO_MOUSEMBP_MOUSEBioGRID15146195 details
PRIO_MOUSEMYPR_MOUSEBioGRID15146195 32325033 details
PRIO_MOUSEGBB1_MOUSEBioGRID15146195 details
PRIO_MOUSEDPYL2_MOUSEBioGRID15146195 details
PRIO_MOUSEPDE10_MOUSEBioGRID15146195 details
PRIO_MOUSESTXB1_MOUSEBioGRID15146195 details
PRIO_MOUSESYN1_MOUSEBioGRID11571277 details
PRIO_MOUSEERI3_MOUSEBioGRID11571277 32325033 details