Entity Details - PICKLE: A Protein InteraCtion KnowLedgebasE

Accession	P00338
EntryName	LDHA_HUMAN
FullName	L-lactate dehydrogenase A chain
TaxID	9606
Evidence	evidence at protein level
Length	332
SequenceStatus	complete
DateCreated	1986-07-21
DateModified	2021-06-02

Genes

LDHA

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GO	Name
GO:0001666	response to hypoxia
GO:0004459	L-lactate dehydrogenase activity
GO:0005634	nucleus
GO:0005829	cytosol
GO:0006089	lactate metabolic process
GO:0006090	pyruvate metabolic process
GO:0006096	glycolytic process
GO:0007584	response to nutrient
GO:0009749	response to glucose
GO:0016020	membrane
GO:0019674	NAD metabolic process
GO:0019900	kinase binding
GO:0021762	substantia nigra development
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0042802	identical protein binding
GO:0043065	positive regulation of apoptotic process
GO:0043627	response to estrogen
GO:0045296	cadherin binding
GO:0048569	post-embryonic animal organ development
GO:0051287	NAD binding
GO:0051591	response to cAMP
GO:0070062	extracellular exosome

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Subcellular Location
Cytoplasm

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Domain	Name	Category	Type
IPR001236	Lactate/malate dehydrogenase, N-terminal	Domain	Domain
IPR001557	L-lactate/malate dehydrogenase	Family	Family
IPR011304	L-lactate dehydrogenase	Family	Family
IPR015955	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal	Family	Homologous superfamily
IPR018177	L-lactate dehydrogenase, active site	Site	Active site
IPR022383	Lactate/malate dehydrogenase, C-terminal	Domain	Domain
IPR036291	NAD(P)-binding domain superfamily	Family	Homologous superfamily

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Drug	Name	Source	Type
DB00157	NADH	Drugbank	small molecule
DB02483	Etheno-NAD	Drugbank	small molecule
DB02701	Nicotinamide	Drugbank	small molecule
DB03940	Oxamic Acid	Drugbank	small molecule
DB09118	Stiripentol	Drugbank	small molecule
DB09130	Copper	Drugbank	small molecule
DB11638	Artenimol	Drugbank	small molecule

1 interaction

Interactor	Partner	Sources	Publications	Link
LDHA_HUMAN	MK13_MOUSE	BioGRID	19135240	details