Entity Details

Primary name HPRT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00492
EntryNameHPRT_HUMAN
FullNameHypoxanthine-guanine phosphoribosyltransferase
TaxID9606
Evidenceevidence at protein level
Length218
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesHPRT1

GO terms

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GOName
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0001913 T cell mediated cytotoxicity
GO:0001975 response to amphetamine
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006164 purine nucleotide biosynthetic process
GO:0006166 purine ribonucleoside salvage
GO:0006168 adenine salvage
GO:0006178 guanine salvage
GO:0007625 grooming behavior
GO:0007626 locomotory behavior
GO:0021756 striatum development
GO:0021895 cerebral cortex neuron differentiation
GO:0021954 central nervous system neuron development
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0042417 dopamine metabolic process
GO:0042802 identical protein binding
GO:0043101 purine-containing compound salvage
GO:0043103 hypoxanthine salvage
GO:0045964 positive regulation of dopamine metabolic process
GO:0046038 GMP catabolic process
GO:0046040 IMP metabolic process
GO:0046100 hypoxanthine metabolic process
GO:0046651 lymphocyte proliferation
GO:0048813 dendrite morphogenesis
GO:0051289 protein homotetramerization
GO:0052657 guanine phosphoribosyltransferase activity
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000836 Phosphoribosyltransferase domainDomainDomain
IPR005904 Hypoxanthine phosphoribosyl transferaseFamilyFamily
IPR029057 Phosphoribosyltransferase-likeFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00352 TioguanineSwissprotsmall molecule
DB00993 AzathioprineDrugbanksmall molecule
DB01033 MercaptopurineDrugbanksmall molecule
DB01632 5-O-phosphono-alpha-D-ribofuranosyl diphosphateDrugbanksmall molecule
DB02309 5-monophosphate-9-beta-D-ribofuranosyl xanthineDrugbanksmall molecule
DB03153 3H-pyrazolo[4,3-d]pyrimidin-7-olDrugbanksmall molecule
DB04356 9-DeazaguanineDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink