Entity Details

Primary name ABL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00519
EntryNameABL1_HUMAN
FullNameTyrosine-protein kinase ABL1
TaxID9606
Evidenceevidence at protein level
Length1130
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesABL1

GO terms

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GOName
GO:0000278 mitotic cell cycle
GO:0000287 magnesium ion binding
GO:0000400 four-way junction DNA binding
GO:0000405 bubble DNA binding
GO:0001784 phosphotyrosine residue binding
GO:0001843 neural tube closure
GO:0001922 B-1 B cell homeostasis
GO:0001934 positive regulation of protein phosphorylation
GO:0002322 B cell proliferation involved in immune response
GO:0002333 transitional one stage B cell differentiation
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0003785 actin monomer binding
GO:0004515 nicotinate-nucleotide adenylyltransferase activity
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005080 protein kinase C binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006298 mismatch repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006464 cellular protein modification process
GO:0006468 protein phosphorylation
GO:0006897 endocytosis
GO:0006914 autophagy
GO:0006974 cellular response to DNA damage stimulus
GO:0006975 DNA damage induced protein phosphorylation
GO:0006979 response to oxidative stress
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007229 integrin-mediated signaling pathway
GO:0008022 protein C-terminus binding
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009791 post-embryonic development
GO:0010506 regulation of autophagy
GO:0010595 positive regulation of endothelial cell migration
GO:0015629 actin cytoskeleton
GO:0016301 kinase activity
GO:0016604 nuclear body
GO:0017124 SH3 domain binding
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019905 syntaxin binding
GO:0021587 cerebellum morphogenesis
GO:0022408 negative regulation of cell-cell adhesion
GO:0030035 microspike assembly
GO:0030036 actin cytoskeleton organization
GO:0030100 regulation of endocytosis
GO:0030145 manganese ion binding
GO:0030155 regulation of cell adhesion
GO:0030425 dendrite
GO:0030514 negative regulation of BMP signaling pathway
GO:0030516 regulation of axon extension
GO:0031113 regulation of microtubule polymerization
GO:0031252 cell leading edge
GO:0031965 nuclear membrane
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0032729 positive regulation of interferon-gamma production
GO:0032743 positive regulation of interleukin-2 production
GO:0032956 regulation of actin cytoskeleton organization
GO:0032991 protein-containing complex
GO:0033690 positive regulation of osteoblast proliferation
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034599 cellular response to oxidative stress
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038189 neuropilin signaling pathway
GO:0038191 neuropilin binding
GO:0042169 SH2 domain binding
GO:0042770 signal transduction in response to DNA damage
GO:0042981 regulation of apoptotic process
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043542 endothelial cell migration
GO:0045184 establishment of protein localization
GO:0045580 regulation of T cell differentiation
GO:0045930 negative regulation of mitotic cell cycle
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046632 alpha-beta T cell differentiation
GO:0046777 protein autophosphorylation
GO:0046875 ephrin receptor binding
GO:0048471 perinuclear region of cytoplasm
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048668 collateral sprouting
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050798 activated T cell proliferation
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0050885 neuromuscular process controlling balance
GO:0051015 actin filament binding
GO:0051019 mitogen-activated protein kinase binding
GO:0051149 positive regulation of muscle cell differentiation
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051353 positive regulation of oxidoreductase activity
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0051496 positive regulation of stress fiber assembly
GO:0051882 mitochondrial depolarization
GO:0051894 positive regulation of focal adhesion assembly
GO:0060020 Bergmann glial cell differentiation
GO:0060563 neuroepithelial cell differentiation
GO:0070064 proline-rich region binding
GO:0070301 cellular response to hydrogen peroxide
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071103 DNA conformation change
GO:0071222 cellular response to lipopolysaccharide
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0072359 circulatory system development
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090135 actin filament branching
GO:0098794 postsynapse
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1900272 negative regulation of long-term synaptic potentiation
GO:1900275 negative regulation of phospholipase C activity
GO:1901216 positive regulation of neuron death
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1903053 regulation of extracellular matrix organization
GO:1903351 cellular response to dopamine
GO:1904528 positive regulation of microtubule binding
GO:1904531 positive regulation of actin filament binding
GO:1905244 regulation of modification of synaptic structure
GO:1905555 positive regulation of blood vessel branching
GO:1990051 activation of protein kinase C activity
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:2000145 regulation of cell motility
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2000251 positive regulation of actin cytoskeleton reorganization
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2000773 negative regulation of cellular senescence
GO:2001020 regulation of response to DNA damage stimulus

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus
Nucleus membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015015 F-actin bindingDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR033221 Tyrosine-protein kinase ABL1/transforming protein AblFamilyFamily
IPR035837 Tyrosine-protein kinase ABL, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule
DB00619 ImatinibDrugbanksmall molecule
DB01254 DasatinibDrugbanksmall molecule
DB03878 N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-PyridinecarboxamideDrugbanksmall molecule
DB04868 NilotinibDrugbanksmall molecule
DB05184 XL228Drugbanksmall molecule
DB06616 BosutinibDrugbanksmall molecule
DB07831 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDEDrugbanksmall molecule
DB08043 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREADrugbanksmall molecule
DB08231 Myristic acidDrugbanksmall molecule
DB08339 PD-166326Drugbanksmall molecule
DB08350 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDEDrugbanksmall molecule
DB08583 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamideDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12267 BrigatinibDrugbanksmall molecule
DB12323 RadotinibDrugbanksmall molecule
DB13749 Magnesium gluconateSwissprotsmall molecule