Entity Details

Primary name EGFR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00533
EntryNameEGFR_HUMAN
FullNameEpidermal growth factor receptor
TaxID9606
Evidenceevidence at protein level
Length1210
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesEGFR

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000165 MAPK cascade
GO:0001503 ossification
GO:0001618 virus receptor activity
GO:0001934 positive regulation of protein phosphorylation
GO:0001942 hair follicle development
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005178 integrin binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006412 translation
GO:0006970 response to osmotic stress
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007275 multicellular organism development
GO:0007494 midgut development
GO:0007611 learning or memory
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell population proliferation
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010750 positive regulation of nitric oxide mediated signal transduction
GO:0010960 magnesium ion homeostasis
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0016101 diterpenoid metabolic process
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019058 viral life cycle
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030054 cell junction
GO:0030154 cell differentiation
GO:0030307 positive regulation of cell growth
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031625 ubiquitin protein ligase binding
GO:0031901 early endosome membrane
GO:0031965 nuclear membrane
GO:0032930 positive regulation of superoxide anion generation
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033590 response to cobalamin
GO:0033594 response to hydroxyisoflavone
GO:0033674 positive regulation of kinase activity
GO:0034614 cellular response to reactive oxygen species
GO:0035690 cellular response to drug
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038128 ERBB2 signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042060 wound healing
GO:0042177 negative regulation of protein catabolic process
GO:0042327 positive regulation of phosphorylation
GO:0042698 ovulation cycle
GO:0042743 hydrogen peroxide metabolic process
GO:0042802 identical protein binding
GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0043586 tongue development
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045296 cadherin binding
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045739 positive regulation of DNA repair
GO:0045740 positive regulation of DNA replication
GO:0045746 negative regulation of Notch signaling pathway
GO:0045780 positive regulation of bone resorption
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045907 positive regulation of vasoconstriction
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046328 regulation of JNK cascade
GO:0046718 viral entry into host cell
GO:0046777 protein autophosphorylation
GO:0048143 astrocyte activation
GO:0048408 epidermal growth factor binding
GO:0048471 perinuclear region of cytoplasm
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048812 neuron projection morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051015 actin filament binding
GO:0051117 ATPase binding
GO:0051205 protein insertion into membrane
GO:0051592 response to calcium ion
GO:0051897 positive regulation of protein kinase B signaling
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060252 positive regulation of glial cell proliferation
GO:0061024 membrane organization
GO:0070141 response to UV-A
GO:0070257 positive regulation of mucus secretion
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070435 Shc-EGFR complex
GO:0071260 cellular response to mechanical stimulus
GO:0071276 cellular response to cadmium ion
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071549 cellular response to dexamethasone stimulus
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097421 liver regeneration
GO:0097489 multivesicular body, internal vesicle lumen
GO:0098609 cell-cell adhesion
GO:1900020 positive regulation of protein kinase C activity
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1901185 negative regulation of ERBB signaling pathway
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902722 positive regulation of prolactin secretion
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1905208 negative regulation of cardiocyte differentiation
GO:2000145 regulation of cell motility

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane
Endosome
Endosome membrane
Golgi apparatus membrane
Nucleus
Nucleus membrane
Secreted

Domains

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DomainNameCategoryType
IPR000494 Receptor L-domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR006211 Furin-like cysteine-rich domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR032778 Growth factor receptor domain 4DomainDomain
IPR036941 Receptor L-domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00002 CetuximabDrugbankbiotech
DB00281 LidocaineDrugbanksmall molecule
DB00317 GefitinibDrugbanksmall molecule
DB00530 ErlotinibDrugbanksmall molecule
DB01259 LapatinibDrugbanksmall molecule
DB01269 PanitumumabDrugbankbiotech
DB03496 AlvocidibDrugbanksmall molecule
DB04988 IGN311Drugbankbiotech
DB05101 MatuzumabDrugbankbiotech
DB05294 VandetanibDrugbanksmall molecule
DB05374 RindopepimutDrugbanksmall molecule
DB05424 CanertinibDrugbanksmall molecule
DB05524 PelitinibDrugbanksmall molecule
DB05944 VarlitinibDrugbanksmall molecule
DB06021 AV-412Drugbanksmall molecule
DB07602 S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINEDrugbanksmall molecule
DB07662 PD-168393Drugbanksmall molecule
DB08916 AfatinibDrugbanksmall molecule
DB09330 OsimertinibDrugbanksmall molecule
DB09559 NecitumumabDrugbankbiotech
DB10772 Foreskin keratinocyte (neonatal)Drugbankbiotech
DB11731 Depatuxizumab mafodotinDrugbankbiotech
DB11737 IcotinibDrugbanksmall molecule
DB11828 NeratinibDrugbanksmall molecule
DB11963 DacomitinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12202 ZalutumumabDrugbankbiotech
DB12267 BrigatinibDrugbanksmall molecule
DB13164 OlmutinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule
DB15327 AbivertinibDrugbanksmall molecule