Entity Details

Primary name THRB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00734
EntryNameTHRB_HUMAN
FullNameProthrombin
TaxID9606
Evidenceevidence at protein level
Length622
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesF2

GO terms

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GOName
GO:0001530 lipopolysaccharide binding
GO:0001934 positive regulation of protein phosphorylation
GO:0004252 serine-type endopeptidase activity
GO:0005102 signaling receptor binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006953 acute-phase response
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007275 multicellular organism development
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0008047 enzyme activator activity
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0009611 response to wounding
GO:0010544 negative regulation of platelet activation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030168 platelet activation
GO:0030193 regulation of blood coagulation
GO:0030194 positive regulation of blood coagulation
GO:0030307 positive regulation of cell growth
GO:0030449 regulation of complement activation
GO:0032967 positive regulation of collagen biosynthetic process
GO:0042730 fibrinolysis
GO:0044267 cellular protein metabolic process
GO:0045861 negative regulation of proteolysis
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0048712 negative regulation of astrocyte differentiation
GO:0050900 leukocyte migration
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051838 cytolysis by host of symbiont cells
GO:0051918 negative regulation of fibrinolysis
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0062023 collagen-containing extracellular matrix
GO:0070053 thrombospondin receptor activity
GO:0070062 extracellular exosome
GO:0070945 neutrophil-mediated killing of gram-negative bacterium
GO:0072562 blood microparticle
GO:0090218 positive regulation of lipid kinase activity
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:1900182 positive regulation of protein localization to nucleus
GO:1900738 positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
GO:2000379 positive regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000001 KringleDomainDomain
IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domainDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR003966 Prothrombin/thrombinFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR018056 Kringle, conserved siteSiteConserved site
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR018992 Thrombin light chainDomainDomain
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyFamilyHomologous superfamily
IPR037111 Thrombin light chain domain superfamilyFamilyHomologous superfamily
IPR038178 Kringle superfamilyFamilyHomologous superfamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00001 LepirudinDrugbankbiotech
DB00006 BivalirudinDrugbanksmall molecule
DB00025 Antihemophilic factor, human recombinantDrugbankbiotech
DB00055 Drotrecogin alfaDrugbankbiotech
DB00100 Coagulation Factor IX (Recombinant)Drugbankbiotech
DB00170 MenadioneDrugbanksmall molecule
DB00278 ArgatrobanDrugbanksmall molecule
DB01123 ProflavineDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB01725 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamideDrugbanksmall molecule
DB01766 Beta-(2-Naphthyl)-AlanineDrugbanksmall molecule
DB01767 Hemi-BabimDrugbanksmall molecule
DB02287 2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidineDrugbanksmall molecule
DB02723 4-Oxo-2-Phenylmethanesulfonyl-Octahydro-Pyrrolo[1,2-a]Pyrazine-6-Carboxylic Acid [1-(N-Hydroxycarbamimidoyl)-Piperidin-4-Ylmethyl]-AmideDrugbanksmall molecule
DB03136 4-Iodobenzo[B]Thiophene-2-CarboxamidineDrugbanksmall molecule
DB03159 CRA_8696Drugbanksmall molecule
DB03847 gamma-carboxy-L-glutamic acidDrugbanksmall molecule
DB03865 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-CarboxamidineDrugbanksmall molecule
DB04136 LysophosphotidylserineDrugbanksmall molecule
DB04591 N-{2,2-DIFLUORO-2-[(2R)-PIPERIDIN-2-YL]ETHYL}-2-[2-(1H-1,2,4-TRIAZOL-1-YL)BENZYL][1,3]OXAZOLO[4,5-C]PYRIDIN-4-AMINEDrugbanksmall molecule
DB04697 TRANS-4-(GUANIDINOMETHYL)-CYCLOHEXANE-L-YL-D-3-CYCLOHEXYLALANYL-L-AZETIDINE-2-YL-D-TYROSINYL-L-HOMOARGININAMIDEDrugbanksmall molecule
DB04722 2-[3-chloro-6-[2,2-difluoro-2-(1-oxidopyridin-1-ium-2-yl)ethyl]imino-1-hydroxypyridin-2-yl]-N-[(1R)-1-(3-chlorophenyl)ethyl]acetamideDrugbanksmall molecule
DB04771 1-GUANIDINO-4-(N-NITRO-BENZOYLAMINO-L-LEUCYL-L-PROLYLAMINO)BUTANEDrugbanksmall molecule
DB04772 1-GUANIDINO-4-(N-PHENYLMETHANESULFONYL-L-LEUCYL-L-PROLYLAMINO)BUTANEDrugbanksmall molecule
DB04786 SuraminDrugbanksmall molecule
DB04898 XimelagatranDrugbanksmall molecule
DB05714 FlovagatranDrugbanksmall molecule
DB05777 Thrombomodulin AlfaDrugbankbiotech
DB06404 Human C1-esterase inhibitorDrugbankbiotech
DB06695 Dabigatran etexilateDrugbanksmall molecule
DB06838 methyl L-phenylalaninateDrugbanksmall molecule
DB06841 [(2R)-1-[(2S)-2-[[(2S,3S)-1-Chloro-6-(diaminomethylideneamino)-2-hydroxyhexan-3-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]azaniumDrugbanksmall molecule
DB06845 (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamideDrugbanksmall molecule
DB06850 (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamideDrugbanksmall molecule
DB06853 N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamideDrugbanksmall molecule
DB06858 N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamideDrugbanksmall molecule
DB06859 N-ALLYL-5-AMIDINOAMINOOXY-PROPYLOXY-3-CHLORO-N-CYCLOPENTYLBENZAMIDEDrugbanksmall molecule
DB06861 6-(2-HYDROXY-CYCLOPENTYL)-7-OXO-HEPTANAMIDINEDrugbanksmall molecule
DB06865 6-CARBAMIMIDOYL-2-[2-HYDROXY-6-(4-HYDROXY-PHENYL)-INDAN-1-YL]-HEXANOIC ACIDDrugbanksmall molecule
DB06866 6-CARBAMIMIDOYL-2-[2-HYDROXY-5-(3-METHOXY-PHENYL)-INDAN-1-YL]-HEXANOIC ACIDDrugbanksmall molecule
DB06868 N-(3-chlorobenzyl)-1-(4-methylpentanoyl)-L-prolinamideDrugbanksmall molecule
DB06869 1-[2-AMINO-2-CYCLOHEXYL-ACETYL]-PYRROLIDINE-3-CARBOXYLIC ACID 5-CHLORO-2-(2-ETHYLCARBAMOYL-ETHOXY)-BENZYLAMIDEDrugbanksmall molecule
DB06878 1-[(2R)-2-aminobutanoyl]-N-(3-chlorobenzyl)-L-prolinamideDrugbanksmall molecule
DB06911 D-leucyl-N-(3-chlorobenzyl)-L-prolinamideDrugbanksmall molecule
DB06919 D-phenylalanyl-N-(3-chlorobenzyl)-L-prolinamideDrugbanksmall molecule
DB06929 1-butanoyl-N-(4-carbamimidoylbenzyl)-L-prolinamideDrugbanksmall molecule
DB06936 N-(4-carbamimidoylbenzyl)-1-(4-methylpentanoyl)-L-prolinamideDrugbanksmall molecule
DB06942 N-(4-carbamimidoylbenzyl)-1-(3-phenylpropanoyl)-L-prolinamideDrugbanksmall molecule
DB06947 1-[(2R)-2-aminobutanoyl]-N-(4-carbamimidoylbenzyl)-L-prolinamideDrugbanksmall molecule
DB06996 D-leucyl-N-(4-carbamimidoylbenzyl)-L-prolinamideDrugbanksmall molecule
DB07005 D-phenylalanyl-N-{4-[amino(iminio)methyl]benzyl}-L-prolinamideDrugbanksmall molecule
DB07016 (3R)-8-(dioxidosulfanyl)-3-methyl-1,2,3,4-tetrahydroquinolineDrugbanksmall molecule
DB07027 D-phenylalanyl-N-(3-fluorobenzyl)-L-prolinamideDrugbanksmall molecule
DB07083 beta-phenyl-D-phenylalanyl-N-propyl-L-prolinamideDrugbanksmall molecule
DB07088 (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamideDrugbanksmall molecule
DB07091 (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamideDrugbanksmall molecule
DB07095 (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamideDrugbanksmall molecule
DB07105 2-[2-(4-Chloro-Phenylsulfanyl)-Acetylamino]-3-(4-Guanidino-Phenyl)-PropionamideDrugbanksmall molecule
DB07120 3-Carbamimidamido-1,1-diphenylureaDrugbanksmall molecule
DB07128 N7-BUTYL-N2-(5-CHLORO-2-METHYLPHENYL)-5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-2,7-DIAMINEDrugbanksmall molecule
DB07131 (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamideDrugbanksmall molecule
DB07133 D-phenylalanyl-N-(3-methylbenzyl)-L-prolinamideDrugbanksmall molecule
DB07143 D-phenylalanyl-N-benzyl-L-prolinamideDrugbanksmall molecule
DB07165 N-(5-CHLORO-BENZO[B]THIOPHEN-3-YLMETHYL)-2-[6-CHLORO-OXO-3-(2-PYRIDIN-2-YL-ETHYLAMINO)-2H-PYRAZIN-1-YL]-ACETAMIDEDrugbanksmall molecule
DB07190 3-cyclohexyl-D-alanyl-N-(3-chlorobenzyl)-L-prolinamideDrugbanksmall molecule
DB07211 (2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDEDrugbanksmall molecule
DB07277 2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDEDrugbanksmall molecule
DB07278 GW-813893Drugbanksmall molecule
DB07279 N-ETHYL-N-ISOPROPYL-3-METHYL-5-{[(2S)-2-(PYRIDIN-4-YLAMINO)PROPYL]OXY}BENZAMIDEDrugbanksmall molecule
DB07353 4-(2,5-DIAMINO-5-HYDROXY-PENTYL)-PHENOLDrugbanksmall molecule
DB07366 2-[N'-(4-AMINO-BUTYL)-HYDRAZINOCARBONYL]-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTERDrugbanksmall molecule
DB07376 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)Drugbanksmall molecule
DB07400 1-ETHOXYCARBONYL-D-PHE-PRO-2(4-AMINOBUTYL)HYDRAZINEDrugbanksmall molecule
DB07440 4-TERT-BUTYLBENZENESULFONIC ACIDDrugbanksmall molecule
DB07461 3-AMINO-3-BENZYL-9-CARBOXAMIDE[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONEDrugbanksmall molecule
DB07508 4-(5-BENZENESULFONYLAMINO-1-METHYL-1H-BENZOIMIDAZOL-2-YLMETHYL)-BENZAMIDINEDrugbanksmall molecule
DB07515 1-(2-{[(6-amino-2-methylpyridin-3-yl)methyl]amino}ethyl)-6-chloro-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-1,4-dihydropyrazin-2-olDrugbanksmall molecule
DB07521 (3Z,6S)-6-Chloro-1-(2-{[(5-chloro-1-benzothiophen-3-yl)methyl]amino}ethyl)-3-({2-[(2R)-2-piperidinyl]ethyl}imino)-2-piperazinolDrugbanksmall molecule
DB07522 N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]NAPHTHALENE-2-SULFONAMIDEDrugbanksmall molecule
DB07527 N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]-4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONAMIDEDrugbanksmall molecule
DB07548 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-6-PYRIDINYL)METHYL]ACETAMIDEDrugbanksmall molecule
DB07549 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-3-METHYL-6-PYRIDINYL)METHYL]ACETAMIDEDrugbanksmall molecule
DB07550 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDO-2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUOROPHENYL)METHYL]ACETAMIDEDrugbanksmall molecule
DB07639 3-(7-DIAMINOMETHYL-NAPHTHALEN-2-YL)-PROPIONIC ACID ETHYL ESTERDrugbanksmall molecule
DB07658 AC-(D)Phe-pro-borolys-OHDrugbanksmall molecule
DB07659 AC-(D)PHE-PRO-BOROHOMOLYS-OHDrugbanksmall molecule
DB07660 AC-(D)PHE-PRO-BOROHOMOORNITHINE-OHDrugbanksmall molecule
DB07665 N-[2-(carbamimidamidooxy)ethyl]-2-{6-cyano-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-fluorophenyl}acetamideDrugbanksmall molecule
DB07718 4-Hydroxyphenylpyruvic acidDrugbanksmall molecule
DB07741 4-(1R,3AS,4R,8AS,8BR)-[1-DIFLUOROMETHYL-2-(4-FLUOROBENZYL)-3-OXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZAMIDINEDrugbanksmall molecule
DB07796 (3ASR,4RS,8ASR,8BRS)-4-(2-(4-FLUOROBENZYL)-1,3-DIOXODEACAHYDROPYRROLO[3,4-A] PYRROLIZIN-4-YL)BENZAMIDINEDrugbanksmall molecule
DB07809 4-({[4-(3-METHYLBENZOYL)PYRIDIN-2-YL]AMINO}METHYL)BENZENECARBOXIMIDAMIDEDrugbanksmall molecule
DB07897 1-(HYDROXYMETHYLENEAMINO)-8-HYDROXY-OCTANEDrugbanksmall molecule
DB07934 [[CYCLOHEXANESULFONYL-GLYCYL]-3[PYRIDIN-4-YL-AMINOMETHYL]ALANYL]PIPERIDINEDrugbanksmall molecule
DB07944 N-{3-METHYL-5-[2-(PYRIDIN-4-YLAMINO)-ETHOXY]-PHENYL}-BENZENESULFONAMIDEDrugbanksmall molecule
DB07946 N-[2-({[amino(imino)methyl]amino}oxy)ethyl]-2-{6-chloro-3-[(2,2-difluoro-2-phenylethyl)amino]-2-fluorophenyl}acetamideDrugbanksmall molecule
DB08061 4-[3-(4-CHLOROPHENYL)-1H-PYRAZOL-5-YL]PIPERIDINEDrugbanksmall molecule
DB08062 3-(4-CHLOROPHENYL)-5-(METHYLTHIO)-4H-1,2,4-TRIAZOLEDrugbanksmall molecule
DB08152 {(2S)-1-[N-(tert-butoxycarbonyl)glycyl]pyrrolidin-2-yl}methyl (3-chlorophenyl)acetateDrugbanksmall molecule
DB08187 N-Methylphenylalanyl-N-[(trans-4-aminocyclohexyl)methyl]-L-prolinamideDrugbanksmall molecule
DB08254 2-Naphthalenesulfonic acidDrugbanksmall molecule
DB08422 [PHENYLALANINYL-PROLINYL]-[2-(PYRIDIN-4-YLAMINO)-ETHYL]-AMINEDrugbanksmall molecule
DB08546 4-[(3AS,4R,7R,8AS,8BR)-2-(1,3-BENZODIOXOL-5-YLMETHYL)-7-HYDROXY-1,3-DIOXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZENECARBOXIMIDAMIDEDrugbanksmall molecule
DB08624 1-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidineDrugbanksmall molecule
DB09109 Turoctocog alfaDrugbankbiotech
DB09130 CopperDrugbanksmall molecule
DB09228 Conestat alfaDrugbankbiotech
DB09332 KappadioneDrugbanksmall molecule
DB11166 Antithrombin AlfaDrugbankbiotech
DB12364 BetrixabanDrugbanksmall molecule
DB12598 NafamostatDrugbanksmall molecule
DB12831 GabexateDrugbanksmall molecule
DB13151 Anti-inhibitor coagulant complexDrugbankbiotech
DB13152 Coagulation Factor IX HumanDrugbankbiotech
DB13998 Lonoctocog alfaDrugbankbiotech
DB13999 Moroctocog alfaDrugbankbiotech
DB14487 Zinc acetateDrugbanksmall molecule
DB14738 Turoctocog alfa pegolDrugbankbiotech

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