Entity Details

Primary name TPA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00750
EntryNameTPA_HUMAN
FullNameTissue-type plasminogen activator
TaxID9606
Evidenceevidence at protein level
Length562
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesPLAT

GO terms

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GOName
GO:0004252 serine-type endopeptidase activity
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0006464 cellular protein modification process
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0009986 cell surface
GO:0014909 smooth muscle cell migration
GO:0031639 plasminogen activation
GO:0042730 fibrinolysis
GO:0045861 negative regulation of proteolysis
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0051219 phosphoprotein binding
GO:0060468 prevention of polyspermy
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000001 KringleDomainDomain
IPR000083 Fibronectin, type IDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR018056 Kringle, conserved siteSiteConserved site
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR026280 Tissue plasminogen activatorFamilyFamily
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR034811 Tissue-type plasminogen activatorFamilyFamily
IPR038178 Kringle superfamilyFamilyHomologous superfamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00513 Aminocaproic acidDrugbanksmall molecule
DB01088 IloprostDrugbanksmall molecule
DB06404 Human C1-esterase inhibitorDrugbankbiotech
DB07684 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACIDDrugbanksmall molecule
DB09213 DexibuprofenDrugbanksmall molecule
DB09228 Conestat alfaDrugbankbiotech

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
TPA_HUMANPLRKT_MOUSEUniProt19897580 details