Entity Details

Primary name A1AT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01009
EntryNameA1AT_HUMAN
FullNameAlpha-1-antitrypsin
TaxID9606
Evidenceevidence at protein level
Length418
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesSERPINA1

GO terms

Show/Hide Table
GOName
GO:0002020 protease binding
GO:0002576 platelet degranulation
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005794 Golgi apparatus
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006953 acute-phase response
GO:0007596 blood coagulation
GO:0010951 negative regulation of endopeptidase activity
GO:0030134 COPII-coated ER to Golgi transport vesicle
GO:0031093 platelet alpha granule lumen
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0042802 identical protein binding
GO:0043231 intracellular membrane-bounded organelle
GO:0043312 neutrophil degranulation
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0048208 COPII vesicle coating
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

Show/Hide Table
Subcellular Location
Endoplasmic reticulum
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR000215 Serpin familyFamilyFamily
IPR023795 Serpin, conserved siteSiteConserved site
IPR023796 Serpin domainDomainDomain
IPR036186 Serpin superfamilyFamilyHomologous superfamily
IPR042178 Serpin superfamily, domain 1FamilyHomologous superfamily
IPR042185 Serpin superfamily, domain 2FamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB01998 2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-TriolDrugbanksmall molecule
DB03345 MercaptoethanolDrugbanksmall molecule
DB05481 Recombinant alpha 1-antitrypsinDrugbankbiotech
DB05961 PPL-100Drugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB14007 Pentetic acidSwissprotsmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink