Entity Details

Primary name A2MG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01023
EntryNameA2MG_HUMAN
FullNameAlpha-2-macroglobulin
TaxID9606
Evidenceevidence at protein level
Length1474
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesA2M

GO terms

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GOName
GO:0001869 negative regulation of complement activation, lectin pathway
GO:0002020 protease binding
GO:0002576 platelet degranulation
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0019838 growth factor binding
GO:0019899 enzyme binding
GO:0019959 interleukin-8 binding
GO:0019966 interleukin-1 binding
GO:0022617 extracellular matrix disassembly
GO:0031093 platelet alpha granule lumen
GO:0043120 tumor necrosis factor binding
GO:0048306 calcium-dependent protein binding
GO:0048863 stem cell differentiation
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0072562 blood microparticle
GO:2000267 negative regulation of blood coagulation, intrinsic pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001599 Alpha-2-macroglobulinDomainDomain
IPR002890 Macroglobulin domainDomainDomain
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroidFamilyHomologous superfamily
IPR009048 Alpha-macroglobulin, receptor-bindingDomainDomain
IPR010916 TonB box, conserved siteSiteConserved site
IPR011625 Alpha-2-macroglobulin, bait region domainDomainDomain
IPR011626 Alpha-macroglobulin-like, TED domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR019742 Alpha-2-macroglobulin, conserved siteSiteConserved site
IPR036595 Alpha-macroglobulin, receptor-binding domain superfamilyFamilyHomologous superfamily
IPR040839 Macroglobulin domain MG4DomainDomain
IPR041555 Macroglobulin domain MG3DomainDomain
IPR041813 Alpha-2-macroglobulin, TED domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00102 BecaplerminDrugbankbiotech
DB00515 CisplatinDrugbanksmall molecule
DB00626 BacitracinDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB06796 MangafodipirSwissprotsmall molecule
DB08888 OcriplasminDrugbankbiotech
DB09130 CopperDrugbanksmall molecule
DB12965 SilverDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
A2MG_HUMANPPIF_MOUSEIntAct32814053 details
A2MG_HUMANNGF_MOUSEBioGRID7686585 details