Entity Details

Primary name MYC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01106
EntryNameMYC_HUMAN
FullNameMyc proto-oncogene protein
TaxID9606
Evidenceevidence at protein level
Length439
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesMYC

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000165 MAPK cascade
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001046 core promoter sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0006112 energy reserve metabolic process
GO:0006338 chromatin remodeling
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006879 cellular iron ion homeostasis
GO:0006974 cellular response to DNA damage stimulus
GO:0007219 Notch signaling pathway
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0010332 response to gamma radiation
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0015671 oxygen transport
GO:0016579 protein deubiquitination
GO:0019221 cytokine-mediated signaling pathway
GO:0032204 regulation of telomere maintenance
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0032986 protein-DNA complex disassembly
GO:0032991 protein-containing complex
GO:0034644 cellular response to UV
GO:0035690 cellular response to drug
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044346 fibroblast apoptotic process
GO:0044877 protein-containing complex binding
GO:0045656 negative regulation of monocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:0048146 positive regulation of fibroblast proliferation
GO:0048147 negative regulation of fibroblast proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051276 chromosome organization
GO:0051782 negative regulation of cell division
GO:0051973 positive regulation of telomerase activity
GO:0070371 ERK1 and ERK2 cascade
GO:0070848 response to growth factor
GO:0070888 E-box binding
GO:0071456 cellular response to hypoxia
GO:0090096 positive regulation of metanephric cap mesenchymal cell proliferation
GO:1904672 regulation of somatic stem cell population maintenance
GO:1904837 beta-catenin-TCF complex assembly
GO:1905643 positive regulation of DNA methylation
GO:2000573 positive regulation of DNA biosynthetic process
GO:2001022 positive regulation of response to DNA damage stimulus

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR002418 Transcription regulator MycFamilyFamily
IPR003327 Leucine zipper, MycDomainDomain
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR012682 Transcription regulator Myc, N-terminalDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB08813 NadroparinDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MYC_HUMANSIN3B_MOUSEIntAct24951594 details
MYC_HUMANSIN3A_MOUSEIntAct24951594 details