Entity Details

Primary name RASH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01112
EntryNameRASH_HUMAN
FullNameGTPase HRas
TaxID9606
Evidenceevidence at protein level
Length189
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesHRAS

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0005829 cytosol
GO:0006935 chemotaxis
GO:0007265 Ras protein signal transduction
GO:0008285 negative regulation of cell population proliferation
GO:0010863 positive regulation of phospholipase C activity
GO:0030335 positive regulation of cell migration
GO:0042088 T-helper 1 type immune response
GO:0042832 defense response to protozoan
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048471 perinuclear region of cytoplasm
GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO:1900029 positive regulation of ruffle assembly
GO:2000630 positive regulation of miRNA metabolic process
GO:0001889 liver development
GO:0001934 positive regulation of protein phosphorylation
GO:0003925 G protein activity
GO:0005794 Golgi apparatus
GO:0008022 protein C-terminus binding
GO:0008284 positive regulation of cell population proliferation
GO:0034260 negative regulation of GTPase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0045740 positive regulation of DNA replication
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0090303 positive regulation of wound healing
GO:0090314 positive regulation of protein targeting to membrane
GO:0090398 cellular senescence
GO:2000251 positive regulation of actin cytoskeleton reorganization
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0003924 GTPase activity
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0006897 endocytosis
GO:0007166 cell surface receptor signaling pathway
GO:0010629 negative regulation of gene expression
GO:0019003 GDP binding
GO:0032729 positive regulation of interferon-gamma production
GO:0043406 positive regulation of MAP kinase activity
GO:0044877 protein-containing complex binding
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050852 T cell receptor signaling pathway
GO:0098978 glutamatergic synapse
GO:0000139 Golgi membrane
GO:0005525 GTP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0007165 signal transduction
GO:0009887 animal organ morphogenesis
GO:0035900 response to isolation stress
GO:0046330 positive regulation of JNK cascade
GO:0048013 ephrin receptor signaling pathway
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071480 cellular response to gamma radiation
GO:0097193 intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Golgi apparatus
Golgi apparatus membrane
Cell membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001806 Small GTPaseFamilyFamily
IPR005225 Small GTP-binding protein domainDomainDomain
IPR020849 Small GTPase, Ras-typeFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02210 Hexane-1,6-DiolDrugbanksmall molecule
DB03226 TrifluoroethanolDrugbanksmall molecule
DB04137 Guanosine-5'-TriphosphateDrugbanksmall molecule
DB04315 Guanosine-5'-DiphosphateDrugbanksmall molecule
DB08751 N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINEDrugbanksmall molecule