Entity Details

Primary name RASK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01116
EntryNameRASK_HUMAN
FullNameGTPase KRas
TaxID9606
Evidenceevidence at protein level
Length189
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesKRAS

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000165 MAPK cascade
GO:0001889 liver development
GO:0001934 positive regulation of protein phosphorylation
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0003924 GTPase activity
GO:0003925 G protein activity
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0007265 Ras protein signal transduction
GO:0007565 female pregnancy
GO:0008284 positive regulation of cell population proliferation
GO:0008542 visual learning
GO:0010628 positive regulation of gene expression
GO:0016020 membrane
GO:0019002 GMP binding
GO:0019003 GDP binding
GO:0019221 cytokine-mediated signaling pathway
GO:0021897 forebrain astrocyte development
GO:0030036 actin cytoskeleton organization
GO:0030275 LRR domain binding
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031647 regulation of protein stability
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0035022 positive regulation of Rac protein signal transduction
GO:0035900 response to isolation stress
GO:0038002 endocrine signaling
GO:0042802 identical protein binding
GO:0043406 positive regulation of MAP kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045596 negative regulation of cell differentiation
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048873 homeostasis of number of cells within a tissue
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0051384 response to glucocorticoid
GO:0051385 response to mineralocorticoid
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:2000774 positive regulation of cellular senescence

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR001806 Small GTPaseFamilyFamily
IPR005225 Small GTP-binding protein domainDomainDomain
IPR020849 Small GTPase, Ras-typeFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB07771 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACIDDrugbanksmall molecule
DB07780 Farnesyl diphosphateDrugbanksmall molecule
DB15568 MRTX849Drugbanksmall molecule
DB15569 AMG-510Drugbanksmall molecule